ArticleDevelopmental cell2011
A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.
Article in Developmental cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harbor perspectives in biology · 2026Article
- ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ThemicroPublication biology · 2025Article
- Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities.G3 (Bethesda, Md.) · 2023Article
- Article
- The conditional growth suppressormicroPublication biology · 2021Article
- Review
- Roles of Membrane and Vesicular Traffic in Regulation of the Hippo Pathway.Frontiers in cell and developmental biology · 2019Review
- Hippo Signaling in Cancer: Lessons FromFrontiers in cell and developmental biology · 2019Review
- Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.Science signaling · 2018Article
- Myopic (HD-PTP, PTPN23) selectively regulates synaptic neuropeptide release.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A mutant O-GlcNAcase enriches Drosophila developmental regulators.Nature chemical biology · 2017Article
- Medium-scale Preparation of Drosophila Embryo Extracts for Proteomic Experiments.Journal of visualized experiments : JoVE · 2017Article
- Single-Step Affinity Purification of ERK Signaling Complexes Using the Streptavidin-Binding Peptide (SBP) Tag.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Australian black field crickets show changes in neural gene expression associated with socially-induced morphological, life-history, and behavioral plasticity.BMC genomics · 2016Article
- Review
- Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp.Scientific reports · 2016Article
- The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled.Molecular biology of the cell · 2015Article
- YAP and TAZ: a nexus for Hippo signaling and beyond.Trends in cell biology · 2015Review
- The ecdysone receptor coactivator Taiman links Yorkie to transcriptional control of germline stem cell factors in somatic tissue.Developmental cell · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian cancers depend on "multiple hits," some of which promote growth and some of which block apoptosis. We screened for mutations that require a synergistic block in apoptosis to promote tissue overgrowth and identified myopic (mop), the Drosophila homolog of the candidate tumor-suppressor and endosomal regulator His-domain protein tyrosine phosphatase (HD-PTP). We find that Myopic regulates the Salvador/Warts/Hippo (SWH) tumor suppressor pathway: Myopic PPxY motifs bind conserved residues in the WW domains of the transcriptional coactivator Yorkie, and Myopic colocalizes with Yorkie at endosomes. Myopic controls Yorkie endosomal association and protein levels, ultimately influencing expression of some Yorkie target genes. However, the antiapoptotic gene diap1 is not affected, which may explain the conditional nature of the myopic growth phenotype. These data establish Myopic as a Yorkie regulator and implicate Myopic-dependent association of Yorkie with endosomal compartments as a regulatory step in nuclear outputs of the SWH pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.