ArticleNeuroImage2011
Serial monitoring of endogenous neuroblast migration by cellular MRI.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Challenges and Practical Solutions to MRI and Histology Matching and Measurements Using Available ImageJ Software Tools.Biomedicines · 2022Article
- Tissue-Specific Ferritin- and GFP-Based Genetic Vectors Visualize Neurons by MRI in the Intact and Post-Ischemic Rat Brain.International journal of molecular sciences · 2020Article
- Review
- In vivo serial MRI of age-dependent neural progenitor cell migration in the rat brain.NeuroImage · 2019Article
- Tracking Neural Progenitor Cell Migration in the Rodent Brain Using Magnetic Resonance Imaging.Frontiers in neuroscience · 2018Review
- Magnetic resonance imaging of odorant activity-dependent migration of neural precursor cells and olfactory bulb growth.NeuroImage · 2017Article
- Advances in Monitoring Cell-Based Therapies with Magnetic Resonance Imaging: Future Perspectives.International journal of molecular sciences · 2017Review
- PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis.Neurogenesis (Austin, Tex.) · 2017Article
- Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Siloxane Nanoprobes for Labeling and Dual Modality Functional Imaging of Neural Stem Cells.Annals of biomedical engineering · 2016Article
- Live Imaging of Adult Neural Stem Cells in Rodents.Frontiers in neuroscience · 2016Review
- 3D mapping of neuronal migration in the embryonic mouse brain with magnetic resonance microimaging.NeuroImage · 2015Article
- In vivo imaging of endogenous neural stem cells in the adult brain.World journal of stem cells · 2015Review
- Clinically viable magnetic poly(lactide-co-glycolide) particles for MRI-based cell tracking.Magnetic resonance in medicine · 2014Article
- Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid.Biochimica et biophysica acta · 2013Article
- Multimodality molecular imaging of stem cells therapy for stroke.BioMed research international · 2013Review
- MRI stem cell tracking for therapy in experimental cerebral ischemia.Translational stroke research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Endogenous neural progenitor cell migration in vivo can be monitored using MRI-based cell tracking. The current protocol is that micron sized iron oxide particles (MPIOs) are injected into the lateral ventricle proximal to the neural stem cell niche in the brain. MPIOs are endocytosed and incorporated into the neural progenitor cell population, making them visible by gradient echo MRI. Here this new method is extended to serially quantify cell migration. Initially, in vivo cell labeling methodologies were optimized, as high susceptibility effects from the MPIOs generate substantial signal loss around the injection site, masking early migratory events. Then, using improved labeling conditions, a longitudinal study was conducted over two weeks to quantify the migration of labeled progenitor cells toward the olfactory bulb (OB). By 3 days following injection, we calculated 0.26% of the volume of the OB containing labeled cells. By 8days, this volume nearly doubled to 0.49% and plateaued. These MRI results are in accordance with our data on iron quantification from the OB and with those from purely immunohistochemical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.