ArticleBioorganic & medicinal chemistry2011
Synthesis and preliminary evaluation of radiolabeled bis(zinc(II)-dipicolylamine) coordination complexes as cell death imaging agents.
Article in Bioorganic & medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Photoacoustic imaging of a cyanine dye targeting bacterial infection.Scientific reports · 2024Article
- Avenues to molecular imaging of dying cells: Focus on cancer.Medicinal research reviews · 2018Review
- Pathogen-Specific Bacterial Imaging in Nuclear Medicine.Seminars in nuclear medicine · 2018Review
- Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes.Chemical communications (Cambridge, England) · 2016Review
- Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death.Bioconjugate chemistry · 2016Article
- Characterization of [(99m)Tc]Duramycin as a SPECT Imaging Agent for Early Assessment of Tumor Apoptosis.Molecular imaging and biology · 2015Article
- Evaluation of [¹¹¹In]-labeled zinc-dipicolylamine tracers for SPECT imaging of bacterial infection.Molecular imaging and biology · 2015Article
- Molecular imaging of apoptosis: from micro to macro.Theranostics · 2015Review
- Bis(zinc-dipicolylamine), Zn-DPA, a new marker for apoptosis.Investigative ophthalmology & visual science · 2014Article
- Molecular imaging of bacterial infections in vivo: the discrimination of infection from inflammation.Informatics (MDPI) · 2014Article
- Article
- Library synthesis, screening, and discovery of modified Zinc(II)-Bis(dipicolylamine) probe for enhanced molecular imaging of cell death.Bioconjugate chemistry · 2014Article
- A low molecular weight zinc2+-dipicolylamine-based probe detects apoptosis during tumour treatment better than an annexin V-based probe.European radiology · 2014Article
- Radiolabeled apoptosis imaging agents for early detection of response to therapy.TheScientificWorldJournal · 2014Review
- Biomarkers and molecular probes for cell death imaging and targeted therapeutics.Bioconjugate chemistry · 2012Review
Corrections and comments
- Erratum issuedMoore, Stephen K [added]
Authors and funding
7 authors.
Funding
Abstract
The aim of this study was the development of (⁹⁹m)Tc labeled bis(zinc(II)-dipicolylamine) (Zn²⁺-DPA) coordination complexes, and the in vivo evaluation of their usefulness as radiotracers for the detection of cell death. DPA ligand 1 was labeled with (⁹⁹m)Tc via the (⁹⁹m)Tc-tricarbonyl core ([(⁹⁹m)Tc(CO)₃-1]³⁺) or via HYNIC ((⁹⁹m)Tc-HYNIC-1) in good radiochemical yields. Highest in vitro stabilities were demonstrated for [(⁹⁹m)Tc(CO)₃-1]³⁺. A mouse model of hepatic apoptosis (anti-Fas mAb) was used to demonstrate binding to apoptotic cells. (⁹⁹m)Tc-HYNIC-1 showed the best targeting of apoptotic hepatic tissue with a 2.2 times higher liver uptake in anti-Fas treated mice as compared to healthy animals. A rat model of ischemia-reperfusion injury was used to further explore the ability of the (⁹⁹m)Tc-labeled Zn²⁺-DPA coordination complexes to target cell death. Selective accumulation could be detected for both tracers in the area at risk, correlating with histological proof of cell death. Area at risk to normal tissue uptake ratios were 3.82 for [(⁹⁹m)Tc(CO)₃-1]³⁺ and 5.45 for (⁹⁹m)Tc-HYNIC-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.