Evidence map›Paper›PMID 21570144›Full record

ReviewInternational journal of food microbiology2012

Integrated stress responses in Salmonella.

Shu Shen, Ferric C Fang

Abstract readReview
In one paragraph

Review in International journal of food microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 63 citations in OpenAlex.

  1. How Salmonella Works Under Osmotic and Desiccation Stresses.Comprehensive reviews in food science and food safety · 2026
    Review
  2. Assessing transcriptomic responses ofMicrobiology spectrum · 2026
    Article
  3. Evaluation of theFrontiers in bioengineering and biotechnology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. RpoS contributes in a host-dependent manner toFrontiers in microbiology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. RpoS-regulatedVirulence · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Cellular Injuries inFrontiers in microbiology · 2018
    Article
  18. Article
  19. Osmosensing by the bacterial PhoQ/PhoP two-component system.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shu ShenDepartments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA, 98195-7242 USA.
Ferric C Fang
University of Washington · US

Funding

THE SALMONELLA TYPHIMURIUM SIGMAE REGULONR01AI044486 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 1999 to 2016
$4.9M
NITRIC OXIDE CYTOTOXICITY IN SALMONELLOSISR01AI039557 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 1997 to 2012
$4.1M
INTERDISCIPLINARY PROGRAM IN BACTERIAL PATHOGENESIST32AI055396 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2003 to 2019
$2.8M
Iron Homeostasis in Salmonella-Host InteractionsR01AI077629 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2009 to 2010
$780k
MECHANISMS OF NITRIC OXIDE CYTOTOXICITY IN SALMONELLOSISR21AI039557 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FANG, FERRIC C · 1996 to 1996
–
NIAID NIH HHS AI39557NIAID NIH HHS AI44486NIAID NIH HHS AI55396NIAID NIH HHS AI77629NIAID NIH HHS R01 AI039557NIAID NIH HHS R01 AI044486NIAID NIH HHS R01 AI077629NIAID NIH HHS T32 AI055396
6 · The paper itself

Abstract

The foodborne gram-negative pathogen Salmonella must adapt to varied environmental conditions encountered within foods, the host gastrointestinal tract and the phagosomes of host macrophages. Adaptation is achieved through the coordinate regulation of gene expression in response to environmental signals such as temperature, pH, osmolarity, redox state, antimicrobial peptides, and nutrient deprivation. This review will examine mechanisms by which the integration of regulatory responses to a broad array of environmental signals can be achieved. First, in the most straightforward case, tandem promoters allow gene expression to respond to multiple signals. Second, versatile sensor proteins may respond to more than one environmental signal. Third, transcriptional silencing and counter-silencing as demonstrated by the H-NS paradigm provides a general mechanism for the convergence of multiple regulatory inputs. Fourth, signaling cascades allow gene activation by independent sensory elements. These mechanisms allow Salmonella to utilize common adaptive stress pathways in response to a diverse range of environmental conditions.

Indexed as

Gene Expression Regulation, BacterialGastrointestinal TractHumansMacrophagesPhagosomesSalmonella entericaSalmonella InfectionsSalmonella typhimuriumSignal TransductionStress, PhysiologicalTranscriptional Activation

Identifiers

PMID21570144
PMCPMC3164900
OpenAlexW2050114181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.