ArticleBiomaterials2011
A 3D aligned microfibrous myocardial tissue construct cultured under transient perfusion.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 80 citations in OpenAlex.
- A study on extracellular and cellular composition to advance towards the rational design of contractile human myocardium.Materials today. Bio · 2026Article
- Tissue Engineering Techniques for Induced Pluripotent Stem Cell Derived Three-Dimensional Cardiac Constructs.Tissue engineering. Part B, Reviews · 2022Review
- Wharton's Jelly-Mesenchymal Stem Cell-Engineered Conduit for Pulmonary Artery Reconstruction in Growing Piglets.JACC. Basic to translational science · 2022Article
- Engineering and Assessing Cardiac Tissue Complexity.International journal of molecular sciences · 2021Review
- Human Cell Modeling for Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- ECM Mimetic Electrospun Porous Poly (L-lactic acid) (PLLA) Scaffolds as Potential Substrates for Cardiac Tissue Engineering.Polymers · 2020Article
- A tissue-engineered scale model of the heart ventricle.Nature biomedical engineering · 2018Article
- In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish.The Journal of physiology · 2017Review
- Artificial Cardiac Muscle with or without the Use of Scaffolds.BioMed research international · 2017Review
- In vitro cardiac tissue models: Current status and future prospects.Advanced drug delivery reviews · 2016Review
- Fibrous scaffolds for building hearts and heart parts.Advanced drug delivery reviews · 2016Review
- [Research process of the preparation of electrostatic spinning of poly-glycerol sebacate and the application in tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2015Article
- [New possibilities for ocular surface reconstruction: collagen membranes and biocompatible elastomer nanofibers].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2014Review
- Electrospun PLGA fibers incorporated with functionalized biomolecules for cardiac tissue engineering.Tissue engineering. Part A · 2014Article
- PGS:Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues.Biomaterials · 2013Article
- Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications.International journal of molecular sciences · 2013Review
- Nanotopography-guided tissue engineering and regenerative medicine.Advanced drug delivery reviews · 2013Review
- Mechanostimulation protocols for cardiac tissue engineering.BioMed research international · 2013Review
- The expanding world of tissue engineering: the building blocks and new applications of tissue engineered constructs.IEEE reviews in biomedical engineering · 2013Review
- Laminar silk scaffolds for aligned tissue fabrication.Macromolecular bioscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The goal of this study was to design and develop a myocardial patch to use in the repair of myocardial infarctions or to slow down tissue damage and improve long-term heart function. The basic 3D construct design involved two biodegradable macroporous tubes, to allow transport of growth media to the cells within the construct, and cell seeded, aligned fiber mats wrapped around them. The microfibrous mat housed mesenchymal stem cells (MSCs) from human umbilical cord matrix (Wharton's Jelly) aligned in parallel to each other in a similar way to cell organization in native myocardium. Aligned micron-sized fiber mats were obtained by electrospinning a polyester blend (PHBV (5% HV), P(L-D,L)LA (70:30) and poly(glycerol sebacate) (PGS)). The micron-sized electrospun parallel fibers were effective in Wharton's Jelly (WJ) MSCs alignment and the cells were able to retract the mat. The 3D construct was cultured in a microbioreactor by perfusing the growth media transiently through the macroporous tubing for two weeks and examined by fluorescence microscopy for cell distribution and preservation of alignment. The fluorescence images of thin sections of 3D constructs from static and perfused cultures confirmed enhanced cell viability, uniform cell distribution and alignment due to nutrient provision from inside the 3D structure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.