ArticleRespiratory physiology & neurobiology2011
Lung and brainstem cytokine levels are associated with breathing pattern changes in a rodent model of acute lung injury.
Article in Respiratory physiology & neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Asthma and sleep disordered breathing in the pediatric adenotonsillectomy trial for snoring study.Sleep & breathing = Schlaf & Atmung · 2024Trial
- Mechanisms associated with progression from lobar inflammation to bilateral lung injury: an experimental study.Respiratory research · 2026Article
- Gastroesophageal Reflux, Sleep-Disordered Breathing, and Outcomes in Patients With Idiopathic Pulmonary Fibrosis.Canadian respiratory journal · 2025Article
- Altered control of breathing in a rat model of allergic lower airway inflammation.Journal of neurophysiology · 2024Article
- Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome.Critical care (London, England) · 2024Article
- A multiscale inflammatory map: linking individual stress to societal dysfunction.Frontiers in science · 2024Article
- Revisiting Asthma Obstructive Sleep Apnea Overlap: Current Knowledge and Future Needs.Journal of clinical medicine · 2023Review
- Cannabinoid Receptor mRNA Expression in Central and Peripheral Tissues in a Rodent Model of Peritonitis.Cannabis and cannabinoid research · 2023Article
- Dynamics of ventilatory pattern variability and Cardioventilatory Coupling during systemic inflammation in rats.Frontiers in network physiology · 2023Article
- Phrenic nerve stimulation mitigates hippocampal and brainstem inflammation in an ARDS model.Frontiers in physiology · 2023Article
- Inappropriate Ventilatory Homeostatic Responses in Hospitalized COVID-19 Patients.Frontiers in neurology · 2022Article
- Perinatal Hypoxemia and Oxygen Sensing.Comprehensive Physiology · 2021Article
- Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth DuringFrontiers in immunology · 2021Article
- A Comparative Assessment of Effects of Major Mediators of Acute Phase Response (IL-1, TNF-α, IL-6) on Breathing Pattern and Survival Rate in Rats with Acute Progressive Hypoxia.Journal of evolutionary biochemistry and physiology · 2021Article
- Proportional modes of ventilation: technology to assist physiology.Intensive care medicine · 2020Review
- Effects of allergic airway inflammation and chronic intermittent hypoxia on systemic blood pressure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy.Journal of cellular and molecular medicine · 2020Article
- Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats.Brain, behavior, and immunity · 2020Article
- Asthma and Obstructive Sleep Apnea Overlap: What Has the Evidence Taught Us?American journal of respiratory and critical care medicine · 2020Review
- Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions.Intensive care medicine · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Acute lung injury evokes a pulmonary inflammatory response and changes in the breathing pattern. The inflammatory response has a centrally mediated component which depends on the vagi. We hypothesize that the central inflammatory response, complimentary to the pulmonary inflammatory response, is expressed in the nuclei tractus solitarii (nTS) and that the expression of cytokines in the nTS is associated with breathing pattern changes. Adult, male Sprague-Dawley rats (n=12) received intratracheal instillation of either bleomycin (3units in 120μl of saline) or saline (120μl). Respiratory pattern changed by 24h. At 48h, bronchoalveolar lavage fluid and lung tissue had increased IL-1β and TNF-α levels, but not IL-6. No changes in these cytokines were noted in serum. Immunocytochemical analysis of the brainstem indicated increased expression of IL-1β in the nTS commissural subnucleus that was localized to neurons. We conclude that breathing pattern changes in acute lung injury were associated with increased levels of IL-1β in brainstem areas which integrate cardio-respiratory sensory input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.