ArticleNutrition journal2011
Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use.
Article in Nutrition journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Bridging the Gap in the Clinical Application of Advanced Parenteral Nutrition Formulations: From Efficacy to Real-World Challenges.Advances in nutrition (Bethesda, Md.) · 2026Review
- Current practices and future directions of stability testing in parenteral nutrition: A scoping review.Asia Pacific journal of clinical nutrition · 2025Article
- Article
- All-in-One Pediatric Parenteral Nutrition Admixtures with an Extended Shelf Life-Insight in Correlations between Composition and Physicochemical Parameters.Pharmaceutics · 2021Article
- Data Mining-Based Stability and Prescription Analysis of Neonatal Parenteral Nutrition Solution.Journal of healthcare engineering · 2021Article
- Pharmaceutical Aspects of Artificial Nutrition.Journal of clinical medicine · 2019Review
- The effect of UV-protected ethylene vinyl acetate (EVA) bags on the physicochemical stability of pediatric parenteral nutrition admixtures.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Article
- Early life nutrition.Science progress · 2018Review
- Ascorbic acid intake and oxalate synthesis.Urolithiasis · 2016Review
- Stability of extemporaneously compounded pyridoxine in glass and plastic bottles and plastic syringes.The Canadian journal of hospital pharmacy · 2014Article
- Pharmaceutical point of view on parenteral nutrition.TheScientificWorldJournal · 2013Review
- Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use.Nutrition journal · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this work was to study the vitamins B1, B2, B6 and C stability in a pediatric formulation containing high amounts of calcium in the presence of organic phosphate, amino acids, glucose, sodium chloride, magnesium sulfate, pediatric vitamins and trace elements under different conditions using developed and validated analytical methods.
methodsThe study was carried out during 72 h with formulations packaged in recommended storage temperature (4°C) and 25°C, with and without photoprotection.
resultsThe results showed that the methodologies used for assessing the chemical stability of vitamins B1, B2, B6 and C in the formulation were selective, linear, precise and accurate. The vitamins could be considered stable in the formulation during the three days of study if stored at 4°C. When stored at 25°C vitamin C presented instability after 48 h.
conclusionThe pediatric formulation containing high amount of calcium in the presence of organic phosphate, amino acids, glucose, sodium chloride, magnesium sulphate, pediatric vitamins and trace elements packaged in bag-type trilaminate presented a shelf life of the 72 h, when maintained under refrigeration, between 2°C and 8°C. This shelf life was measured considering the vitamins studied. Further studies are needed including all the vitamins present in this formulation.
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Registered trials
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