ArticleBMC public health2011
Interplay between heritability of smoking and environmental conditions? A comparison of two birth cohorts.
Article in BMC public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Pooled it
- Association of infrarenal aortic diameter in siblings within the Stockholm abdominal aortic aneurysm screening programme.The British journal of surgery · 2026Article
- Cohort Effects on Tobacco Consumption and Its Genetic and Environmental Variance Among Finnish Adults Born Between 1880 and 1957.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study.BMC medicine · 2023Article
- Rare genetic variants explain missing heritability in smoking.Nature human behaviour · 2022Article
- Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status.Behavior genetics · 2022Article
- Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice.Frontiers in neuroscience · 2022Article
- Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging.Medicine and science in sports and exercise · 2021Article
- Analysis of the Relationship between Tobacco Smoking and Physical Activity in Adolescence: A Gender Specific Study.Medicina (Kaunas, Lithuania) · 2021Article
- Effects of Social Attitude Change on Smoking Heritability.Behavior genetics · 2018Article
- Narrative review of genes, environment, and cigarettes.Annals of medicine · 2016Review
- Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.Human genetics · 2016Article
- Cohort Effects in the Genetic Influence on Smoking.Behavior genetics · 2016Article
- Family resemblance of bone turnover rate in mothers and daughters--the MODAM study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Genetic and environmental etiology of nicotine use in Sri Lankan male twins.Behavior genetics · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundAttitudes and policy towards smoking changed over the past years in many countries including the Netherlands. Generally, this led to a decrease in smoking prevalence. As demonstrated in twin and family studies, individual differences in smoking behavior are partly influenced by genetic factors. We explore whether the current change in environmental conditions has influenced the genetic architecture of smoking. This would constitute evidence for Gene × Environment (G×E) interaction.
methodsData on smoking were available from 2 cohorts of young adult twins (18-25 year) registered with the Netherlands Twin Register. The first cohort completed a survey in 1993-1995 (n = 2669) and the second in 2009-2010 (n = 2339). Prevalence and genetic architecture of smoking were compared across cohorts using structural equation models in MX.
resultsSmoking prevalence decreased from 40-51% to 22-23% between 1993-1995 and 2009-2010. Genetic analyses, making use of the different genetic resemblance in monozygotic and dizygotic twins, showed that the heritability was the same in both cohorts.
conclusionsThe change in policy and smoking attitudes that led to a decrease in prevalence of smoking did not change the heritability of smoking and thus no evidence was found for GxE interaction.
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