ArticleCritical care (London, England)2011
Injurious mechanical ventilation affects neuronal activation in ventilated rats.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Systematic review of cognitive impairment and brain insult after mechanical ventilation.Critical care (London, England) · 2021Pooled it
- Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.International journal of molecular sciences · 2026Review
- Decoding mechanisms and protein markers in lung-brain axis.Respiratory research · 2025Review
- Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation.Scientific reports · 2025Article
- Beyond the Lungs: Extrapulmonary Effects of Non-Invasive and Invasive Ventilation Strategies.Journal of clinical medicine · 2025Review
- Organ crosstalk: brain-lung interaction.Frontiers in medicine · 2025Review
- Negative Pressure Ventilation Can Prevent Ventilator-associated Brain Injury.American journal of respiratory and critical care medicine · 2024Article
- Ventilator-associated Brain Injury: A New Priority for Research in Mechanical Ventilation.American journal of respiratory and critical care medicine · 2024Article
- Incidence and Outcomes of Acute Respiratory Distress Syndrome in Brain-Injured Patients Receiving Invasive Ventilation: A Secondary Analysis of the ENIO Study.Journal of intensive care medicine · 2024Article
- Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.Journal of neuroinflammation · 2023Article
- Lung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.Research square · 2023Article
- Phrenic nerve stimulation mitigates hippocampal and brainstem inflammation in an ARDS model.Frontiers in physiology · 2023Article
- Systemic interleukin-6 inhibition ameliorates acute neuropsychiatric phenotypes in a murine model of acute lung injury.Critical care (London, England) · 2022Article
- ARDS associated acute brain injury: from the lung to the brain.European journal of medical research · 2022Review
- Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release.Bioengineered · 2022Review
- Article
- Molecular mechanisms of postintensive care syndrome.Intensive care medicine experimental · 2021Review
- IL-6 Inhibition Reduces Neuronal Injury in a Murine Model of Ventilator-induced Lung Injury.American journal of respiratory cell and molecular biology · 2021Article
- Crosstalk Between Lung and Extrapulmonary Organs in Infection and Inflammation.Advances in experimental medicine and biology · 2021Review
- Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies.Intensive care medicine experimental · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSurvivors of critical illness often have significant long-term brain dysfunction, and routine clinical procedures like mechanical ventilation (MV) may affect long-term brain outcome. We aimed to investigate the effect of the increase of tidal volume (Vt) on brain activation in a rat model.
methodsMale Sprague Dawley rats were randomized to three groups: 1) Basal: anesthetized unventilated animals, 2) low Vt (LVt): MV for three hours with Vt 8 ml/kg and zero positive end-expiratory pressure (ZEEP), and 3) high Vt (HVt) MV for three hours with Vt 30 ml/kg and ZEEP. We measured lung mechanics, mean arterial pressure (MAP), arterial blood gases, and plasma and lung levels of cytokines. We used immunohistochemistry to examine c-fos as a marker of neuronal activation. An additional group of spontaneously breathing rats was added to discriminate the effect of surgical procedure and anesthesia in the brain.
resultsAfter three hours on LVt, PaO2 decreased and PaCO2 increased significantly. MAP and compliance remained stable in MV groups. Systemic and pulmonary inflammation was higher in MV rats than in unventilated rats. Plasma TNFα was significantly higher in HVt than in LVt. Immunopositive cells to c-fos in the retrosplenial cortex and thalamus increased significantly in HVt rats but not in LVt or unventilated rats.
conclusionsMV promoted brain activation. The intensity of the response was higher in HVt animals, suggesting an iatrogenic effect of MV on the brain. These findings suggest that this novel cross-talking mechanism between the lung and the brain should be explored in patients undergoing MV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.