Evidence map›Paper›PMID 21569407›Full record

ArticleBMC medicine2011

Results from evaluations of models and cost-effectiveness tools to support introduction decisions for new vaccines need critical appraisal.

Raymond Hutubessy, Ana Maria Henao, Pem Namgyal, Vasee Moorthy, Joachim Hombach

Abstract read
In one paragraph

Article in BMC medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
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  13. Modeling cholera outbreaks.Current topics in microbiology and immunology · 2014
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  18. Dynamic transmission modeling: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force--5.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raymond HutubessyInitiative for Vaccine Research, Immunization, Biologicals and Vaccines Department, World Health Organization, 20 Avenue Appia, CH-1210 Geneva, Switzerland. hutubessyr@who.int
Ana Maria Henao
Pem Namgyal
Vasee Moorthy
Joachim Hombach

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The World Health Organization (WHO) recommends that the cost-effectiveness (CE) of introducing new vaccines be considered before such a programme is implemented. However, in low- and middle-income countries (LMICs), it is often challenging to perform and interpret the results of model-based economic appraisals of vaccines that benefit from locally relevant data. As a result, WHO embarked on a series of consultations to assess economic analytical tools to support vaccine introduction decisions for pneumococcal, rotavirus and human papillomavirus vaccines. The objectives of these assessments are to provide decision makers with a menu of existing CE tools for vaccines and their characteristics rather than to endorse the use of a single tool. The outcome will provide policy makers in LMICs with information about the feasibility of applying these models to inform their own decision making. We argue that if models and CE analyses are used to inform decisions, they ought to be critically appraised beforehand, including a transparent evaluation of their structure, assumptions and data sources (in isolation or in comparison to similar tools), so that decision makers can use them while being fully aware of their robustness and limitations.

Indexed as

Cost-Benefit AnalysisEvaluation Studies as TopicHumansModels, StatisticalPapillomavirus InfectionsPneumococcal InfectionsRotavirus InfectionsRotavirus VaccinesVaccinationRotavirus Vaccines

Identifiers

PMID21569407
PMCPMC3117725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.