ArticleVirology journal2011
Antiviral activity of Acacia nilotica against Hepatitis C Virus in liver infected cells.
Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Characterization and anticancer bioactivity of the fungal immunomodulatory protein FIP-Gre from Ganoderma resinaceum.Molecular biology reports · 2026Article
- The Acacia (Nutrients · 2024Review
- Investigation of phytochemicals isolated from selected Saudi medicinal plants as natural inhibitors of SARS CoV-2 main protease: In vitroSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Anti-quorum sensing and biofilm inhibitory effect of some medicinal plants against gram-negative bacterial pathogens:Heliyon · 2022Article
- Integrated System Pharmacology Approaches to Elucidate Multi-Target Mechanism ofMolecules (Basel, Switzerland) · 2022Article
- Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria.European journal of integrative medicine · 2022Article
- Article
- Eruca sativa seed napin structural insights and thorough functional characterization.Scientific reports · 2021Article
- Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation.Drug design, development and therapy · 2021Review
- Luteolin and abyssinone II as potential inhibitors of SARS-CoV-2: an in silico molecular modeling approach in battling the COVID-19 outbreak.Bulletin of the National Research Centre · 2021Article
- Computational prediction of nimbanal as potential antagonist of respiratory syndrome coronavirus.Informatics in medicine unlocked · 2021Article
- Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone.Journal of infection and public health · 2020Article
- Phytotherapeutic options for the treatment of COVID-19: A concise viewpoint.Phytotherapy research : PTR · 2020Article
- Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 MLife sciences · 2020Article
- Review on medicinal plants and natural compounds as anti-Onchocerca agents.Parasitology research · 2018Review
- Phytochemical profiling and antiviral activity of Ajuga bracteosa, Ajuga parviflora, Berberis lycium and Citrus lemon against Hepatitis C Virus.Microbial pathogenesis · 2018Article
- Impact of IL12B gene rs 3212227 polymorphism on fibrosis, liver inflammation, and response to treatment in genotype 4 Egyptian hepatitis C patients.Disease markers · 2013Article
- Molecular screening of phytochemicals from Amelanchier Alnifolia against HCV NS3 protease/helicase using computational docking techniques.Bioinformation · 2013Article
- Computer aided screening of Accacia nilotica phytochemicals against HCV NS3/4a.Bioinformation · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) belonging to the family Flaviviridae has infected 3% of the population worldwide and 6% of the population in Pakistan. The only recommended standard treatment is pegylated INF-α plus ribavirin. Due to less compatibility of the standard treatment, thirteen medicinal plants were collected from different areas of Pakistan on the basis of undocumented antiviral reports against different viral infections. Medicinal plants were air dried, extracted and screened out against HCV by infecting HCV inoculums of 3a genotype in liver cells. RT-PCR results demonstrate that acetonic and methanolic extract of Acacia nilotica (AN) showed more than 50% reduction at non toxic concentration. From the above results, it can be concluded that by selecting different molecular targets, specific structure-activity relationship can be achieved by doing mechanistic analysis. So, additional studies are required for the isolation and recognition of antiviral compound in AN to establish its importance as antiviral drug against HCV. For further research, we will scrutinize the synergistic effect of active antiviral compound in combination with standard PEG INF-α and ribavirin which may be helpful in exploring further gateways for antiviral therapy against HCV.
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