ArticleBMC evolutionary biology2011
Evolution of MIR159/319 microRNA genes and their post-transcriptional regulatory link to siRNA pathways.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 73 citations in OpenAlex.
- The miR319/bHLH094 Module Regulates Creeping Bentgrass Thermotolerance by Modulating Auxin Biosynthesis and Signalling Pathway.Plant biotechnology journal · 2026Article
- Integrative Roles of miRNAs and circRNAs in Plant Antiviral Gene Regulation and Autophagy.Plants (Basel, Switzerland) · 2025Review
- Unraveling the Multilayered Regulatory Networks of miRNAs and PhasiRNAs inPlants (Basel, Switzerland) · 2025Article
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- Conserved and non-conserved RNA-target modules in plants: lessons for a better understanding of Marchantia development.Plant molecular biology · 2023Review
- Parallel analysis of RNA ends reveals global microRNA-mediated target RNA cleavage in maize.The Plant journal : for cell and molecular biology · 2022Article
- Advances in the regulation of plant salt-stress tolerance by miRNA.Molecular biology reports · 2022Review
- Evolutionary conservation of nested MIR159 structural microRNA genes and their promoter characterization inFrontiers in plant science · 2022Article
- Nested miRNA Secondary Structure Is a Unique Determinant of miR159 Efficacy inFrontiers in plant science · 2022Article
- Novel approaches on identification of conserved miRNAs for broad-spectrum Potyvirus control measures.Molecular biology reports · 2021Article
- Systematic Characterization of MicroRNA Processing Modes in Plants With Parallel Amplification of RNA Ends.Frontiers in plant science · 2021Article
- The Regulation of CIN-like TCP Transcription Factors.International journal of molecular sciences · 2020Review
- Review
- Evolution of MIR159/319 genes in Brassica campestris and their function in pollen development.Plant molecular biology · 2019Article
- Biology and Function of miR159 in Plants.Plants (Basel, Switzerland) · 2019Review
- Comparative genomics reveals origin of MIR159A-MIR159B paralogy, and complexities of PTGS interaction between miR159 and target GA-MYBs in Brassicaceae.Molecular genetics and genomics : MGG · 2019Article
- Genome-Wide Identification of Putative MicroRNAs in Cassava (BioMed research international · 2019Article
- Alternative processing of its precursor is related to miR319 decreasing in melon plants exposed to cold.Scientific reports · 2018Article
- High-throughput sequencing analysis revealed the regulation patterns of small RNAs on the development of A. comosus var. bracteatus leaves.Scientific reports · 2018Article
- Small RNA Activity in Archeological Barley Shows Novel Germination Inhibition in Response to Environment.Molecular biology and evolution · 2017Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) are prevalent and important endogenous gene regulators in eukaryotes. MiR159 and miR319 are highly conserved miRNAs essential for plant development and fertility. Despite high similarity in conservation pattern and mature miRNA sequences, miR159 and miR319 have distinct expression patterns, targets and functions. In addition, both MIR319 and MIR159 precursors produce multiple miRNAs in a phased loop-to-base manner. Thus, MIR159 and MIR319 appear to be related in origin and considerably diverged. However the phylogeny of MIR159 and MIR319 genes and why such unusual style of miRNA production has been conserved during evolution is not well understood.
resultsWe reconstructed the phylogeny of MIR159/319 genes and analyzed their mature miRNA expression. The inferred phylogeny suggests that the MIR159/319 genes may have formed at least ten extant early-branching clades through gene duplication and loss. A series of duplications occurred in the common ancestor of seed plants leading to the original split of flowering plant MIR159 and MIR319. The results also indicate that the expression of MIR159/319 is regulated at post-transcriptional level to switch on the expression of alternative miRNAs during development in a highly spatio-temporal specific manner, and to selectively respond to the disruption of defensive siRNA pathways. Such intra-stem-loop regulation appears diverged across the early-branching clades of MIR159/319 genes.
conclusionsOur results support that the MIR159 and MIR319 genes evolve from a common ancestor, which is likely to be a phased stem-loop small RNA. Through duplication and loss of genes this miRNA gene family formed clades specific to moss, lycopods, gymnosperms and angiosperms including the two major clades of flowering plants containing the founding members of MIR319 and MIR159 genes in A.thaliana. Our analyses also suggest that some MIR159/319 have evolved into unusual miRNA genes that are regulated at post-transcriptional level to express multiple mature products with variable proportions under different circumstances. Moreover, our analyses reveal conserved regulatory link of MIR159/319 genes to siRNA pathway through post-transcriptional regulation.
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