ArticleGenome biology2011
Modulated contact frequencies at gene-rich loci support a statistical helix model for mammalian chromatin organization.
Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Identifying chromatin features that regulate gene expression distribution.Scientific reports · 2020Article
- Review
- Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains.BMC genomics · 2015Article
- Review
- Orthogonal control of expression mean and variance by epigenetic features at different genomic loci.Molecular systems biology · 2015Article
- Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition.Genome research · 2014Article
- Long non-coding RNA identification over mouse brain development by integrative modeling of chromatin and genomic features.Nucleic acids research · 2013Article
- H19 antisense RNA can up-regulate Igf2 transcription by activation of a novel promoter in mouse myoblasts.PloS one · 2012Article
- Is chromatin helical?Nature reviews. Molecular cell biology · 2011Article
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10 authors.
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Abstract
backgroundDespite its critical role for mammalian gene regulation, the basic structural landscape of chromatin in living cells remains largely unknown within chromosomal territories below the megabase scale.
resultsHere, using the 3C-qPCR method, we investigate contact frequencies at high resolution within interphase chromatin at several mouse loci. We find that, at several gene-rich loci, contact frequencies undergo a periodical modulation (every 90 to 100 kb) that affects chromatin dynamics over large genomic distances (a few hundred kilobases). Interestingly, this modulation appears to be conserved in human cells, and bioinformatic analyses of locus-specific, long-range cis-interactions suggest that it may underlie the dynamics of a significant number of gene-rich domains in mammals, thus contributing to genome evolution. Finally, using an original model derived from polymer physics, we show that this modulation can be understood as a fundamental helix shape that chromatin tends to adopt in gene-rich domains when no significant locus-specific interaction takes place.
conclusionsAltogether, our work unveils a fundamental aspect of chromatin dynamics in mammals and contributes to a better understanding of genome organization within chromosomal territories.
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