ArticleVirology journal2011
Dynamic variations in the peripheral blood lymphocyte subgroups of patients with 2009 pandemic H1N1 swine-origin influenza A virus infection.
Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influenced by a Synbiotic: a Randomised Controlled Trial.Frontiers in immunology · 2018Trial
- Trial
- Observational
- Human Innate Lymphoid Cells in Influenza Infection and Vaccination.Critical reviews in immunology · 2021Review
- Specific dynamic variations in the peripheral blood lymphocyte subsets in COVID-19 and severe influenza A patients: a retrospective observational study.BMC infectious diseases · 2020Observational
- Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8Journal of virology · 2017Article
- Dynamic variations of the peripheral blood immune cell subpopulation in patients with critical H7N9 swine-origin influenza A virus infection: A retrospective small-scale study.Experimental and therapeutic medicine · 2017Article
- Innate immune sensing and response to influenza.Current topics in microbiology and immunology · 2015Article
- Efficacy of lung recruitment maneuver with high-level positive end-expiratory pressure in patients with influenza-associated acute respiratory distress: a single-center prospective study.Current therapeutic research, clinical and experimental · 2013Article
- Influenza virus infection but not H1N1 influenza virus immunization is associated with changes in peripheral blood NK cell subset levels.Clinical and vaccine immunology : CVI · 2013Article
- Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity.Scientific reports · 2013Article
- High titer and avidity of nonneutralizing antibodies against influenza vaccine antigen are associated with severe influenza.Clinical and vaccine immunology : CVI · 2012Article
- Two years after pandemic influenza A/2009/H1N1: what have we learned?Clinical microbiology reviews · 2012Review
- Chronically HIV-1 Infected Patients Exhibit Low Frequencies of CD25+ Regulatory T Cells.The open virology journal · 2012Article
- Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience.Current opinion in virology · 2011Review
- High incidence of severe influenza among individuals over 50 years of age.Clinical and vaccine immunology : CVI · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNovel Influenza A (H1N1) is an acute respiratory infectious disease. Animal experiments indicated that when H1N1 virus infected early hosts, it showed strong CD4(+), CD8(+), and CD4(+)CD25(+) T cell reactions. The aim of this study was to investigate the dynamic fluctuations of the peripheral blood lymphocyte subgroups in patients infected with H1N1 swine-origin influenza A virus (S-OIV).
methodsThe frequency of T cells, B cells, natural killer (NK) cells, and regulatory T cells (Treg) in 36 severe H1N1 and 40 moderate H1N1 patients were detected at different periods by flow cytometry. In parallel, serum cytokines were detected by enzyme-linked immunosorbent assay and C-reactive protein (CRP) was analyzed through an image-type automatic biochemical analyzer. In addition, 20 healthy volunteers, who were not infected with 2009 H1N1 virus, were selected as controls.
resultsThe frequency of NK cells were decreased in all cases and CD19(+) B cells were increased in severe cases than those of the controls. At 1-2d from onset, the frequency of CD4(+) and CD4(+)CD25(+) T cells in moderate cases was higher than in the severe cases. Serum cytokines, specifically IL-2, IL-4, IL-6, IL-10, and IFN-γ exhibited no significant change both in the moderate and the severe cases during the whole monitoring process. In the early stage of the disease, serum CRP levels in the severe and moderate groups were significantly higher than that in the control group.
conclusionsPatients showed different lymphocyte subgroup distributions between mild and severe cases, which might affect the incidence and development of 2009 H1N1.
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