ArticleJournal of evolutionary biology2011
The decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity.
Article in Journal of evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
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- SuSha: A multi-model ensemble learning framework for predicting microbial salinity adaptation.Engineering microbiology · 2026Article
- Identification of specific metabolic capacities associated with major extraintestinal pathogenicJournal of bacteriology · 2026Article
- Temporal dynamics of the fecal microbiota in veal calves in a 6-month field trial.Animal microbiome · 2020Article
- Genomic epidemiology and carbon metabolism of Escherichia coli serogroup O145 reflect contrasting phylogenies.PloS one · 2020Article
- Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.Emerging infectious diseases · 2019Article
- Each of 3,323 metabolic innovations in the evolution ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Day-to-Day Dynamics of Commensal Escherichia coli in Zimbabwean Cows Evidence Temporal Fluctuations within a Host-Specific Population Structure.Applied and environmental microbiology · 2017Article
- Adaptive evolution of complex innovations through stepwise metabolic niche expansion.Nature communications · 2016Article
- The phenotypic signature of adaptation to thermal stress in Escherichia coli.BMC evolutionary biology · 2015Article
- Tackling Drug Resistant Infection Outbreaks of Global Pandemic Escherichia coli ST131 Using Evolutionary and Epidemiological Genomics.Microorganisms · 2015Review
- Long-term phenotypic evolution of bacteria.Nature · 2015Article
- Evidence for coexistence of distinct Escherichia coli populations in various aquatic environments and their survival in estuary water.Applied and environmental microbiology · 2013Article
- Fitness, stress resistance, and extraintestinal virulence in Escherichia coli.Infection and immunity · 2013Article
- Phenotype profiling of Rhizobium leguminosarum bv. trifolii clover nodule isolates reveal their both versatile and specialized metabolic capabilities.Archives of microbiology · 2013Article
- Synthetic approaches to understanding biological constraints.Current opinion in chemical biology · 2012Review
- Variation in endogenous oxidative stress in Escherichia coli natural isolates during growth in urine.BMC microbiology · 2012Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To assess the extent of intra-species diversity and the links between phylogeny, lifestyle (habitat and pathogenicity) and phenotype, we assayed the growth yield on 95 carbon sources of 168 Escherichia strains. We also correlated the growth capacities of 14 E. coli strains with the presence/absence of enzyme-coding genes. Globally, we found that the genetic distance, based on multilocus sequence typing data, was a weak indicator of the metabolic phenotypic distance. Besides, lifestyle and phylogroup had almost no impact on the growth yield of non-Shigella E. coli strains. In these strains, the presence/absence of the metabolic pathways, which was linked to the phylogeny, explained most of the growth capacities. However, few discrepancies blurred the link between metabolic phenotypic distance and metabolic pathway distance. This study shows that a prokaryotic species structured into well-defined genetic and lifestyle groups can yet exhibit continuous phenotypic diversity, possibly caused by gene regulatory effects.
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