ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2011
Trends in diagnosis and surgical management of patients with perforated peptic ulcer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Perioperative Outcomes of No-Drain Strategy in Primary Repair of Perforated Peptic Ulcer: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Perforated peptic ulcers in children: a systematic review.BMC pediatrics · 2025Pooled it
- Perforated and bleeding peptic ulcer: WSES guidelines.World journal of emergency surgery : WJES · 2020Guideline
- Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Pooled it
- An Updated Meta-Analysis of Laparoscopic Versus Open Repair for Perforated Peptic Ulcer.Scientific reports · 2015Pooled it
- Primary versus delayed primary skin closure in operated patients due to perforated peptic ulcer disease: a randomized controlled clinical trial.Langenbeck's archives of surgery · 2022Trial
- Factors contributing to bleeding and perforated peptic ulcers in Syria: findings from a multicenter cohort study.International journal of emergency medicine · 2025Article
- Laparoscopic surgery in acute perforated gastroduodenal ulcers: an underutilized technique despite favorable short-term outcomes.Surgical endoscopy · 2025Article
- Magnitude, outcome, and predictors of mortality in perforated peptic ulcer disease: a retrospective study in Jigjiga town, Ethiopia.World journal of emergency surgery : WJES · 2025Article
- Perforated peptic ulcer in pregnancy and puerperium: A systematic review.World journal of gastrointestinal surgery · 2025Article
- Retrospective comparative study of different surgical methods for gastric ulcer perforation: Efficacy and postoperative complications.World journal of gastrointestinal surgery · 2025Article
- Article
- A comparative study on laparoscopic and open surgical approaches for perforated peptic ulcer repair: efficacy and outcomes analysis.Langenbeck's archives of surgery · 2023Article
- A simple and effective technique for laparoscopic gastrorrhaphy: modified Graham's patch with barbed suture.BMC surgery · 2023Article
- Predicting in-hospital mortality risk for perforated peptic ulcer surgery: the PPUMS scoring system and the benefit of laparoscopic surgery: a population-based study.Surgical endoscopy · 2023Article
- Early post-operative morbidity and mortality predictors in peptic ulcer perforation.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- A pilot study to evaluate the effectiveness and safety of urgent endoscopy for gastroduodenal perforation.Surgical endoscopy · 2022Article
- Outcomes of omental patch repair in large or giant perforated peptic ulcer are comparable to gastrectomy.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Pattern of Presentation, Management and Early Outcome in Patients with Perforated Peptic Ulcer Disease in a Semi-urban Tertiary Hospital.Ethiopian journal of health sciences · 2021Article
- Optimal treatment and complications of patients with the perforated upper gastrointestinal tract.Surgery today · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWhile the laparoscopic treatment of perforated peptic ulcers (PPU) has been shown to be feasible and safe, its implementation into routine clinical practice has been slow. Only a few studies have evaluated its overall utility. The aim of this study was to investigate changes in surgical management of PPU and associated outcomes. MATERIAL AND
methodsThe study was a retrospective, single institution, population-based review of all patients undergoing surgery for PPU between 2003 and 2009. Patient demographics, diagnostic evaluation, management, and outcomes were evaluated.
resultsIncluded were 114 patients with a median age of 67 years (range, 20-100). Women comprised 59% and were older (p < 0.001), had more comorbidities (p = 0.002), and had a higher Boey risk score (p = 0.036) compared to men. Perforation location was gastric/pyloric in 72% and duodenal in 28% of patients. Pneumoperitoneum was diagnosed by plain abdominal x-ray in 30 of 41 patients (75%) and by abdominal computerized tomography (CT) in 76 of 77 patients (98%; p < 0.001).Laparoscopic treatment was initiated in 48 patients (42%) and completed in 36 patients (75% of attempted cases). Laparoscopic treatment rate increased from 7% to 46% during the study period (p = 0.02). Median operation time was shorter in patients treated via laparotomy (70 min) compared to laparoscopy (82 min) and those converted from laparoscopy to laparotomy (105 min; p = 0.017). Postoperative complications occurred in 56 patients (49%). Overall 30-day postoperative mortality was 16%. No statistically significant differences were found in morbidity and mortality between open versus laparoscopic repair.
conclusionThis study demonstrates an increased use of CT as the primary diagnostic tool for PPU and of laparoscopic repair in its surgical treatment. These changes in management are not associated with altered outcomes.
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