ArticleInternational journal of clinical pharmacy2011
Extent and nature of unlicensed and off-label medicine use in hospitalised children in Palestine.
Article in International journal of clinical pharmacy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Use of off-label and unlicenced drugs in hospitalised paediatric patients: a systematic review.European journal of clinical pharmacology · 2015Pooled it
- Off-Label Drug Use in Pediatric Out-Patient Care: A Multi-Center Observational Study.Hospital pharmacy · 2021Article
- Extent, reasons and consequences of off-labeled and unlicensed drug prescription in hospitalized children: a narrative review.World journal of pediatrics : WJP · 2021Review
- No Time for Lullabies Tracing down Pharmacological Effects & Uses of H1-Antihistamines in Children Younger than 6 Years.Global pediatric health · 2021Article
- High prevalence of off-label and unlicensed paediatric prescribing in a hospital in Indonesia during the period Aug.-Oct. 2014.PloS one · 2020Article
- The Unlicensed and Off-label Prescription of Medications in General Paediatric Ward: An Observational Study.Current pediatric reviews · 2019Observational
- Two decades of off-label prescribing in children: a literature review.World journal of pediatrics : WJP · 2018Review
- Unlicensed and off-label use of drugs in pediatric surgical units at tertiary care hospitals of Pakistan.International journal of clinical pharmacy · 2017Observational
- Off-label use of antimicrobials in neonates in a tertiary children's hospital.European journal of clinical pharmacology · 2017Article
- Magistral drugs in hospitalized newborns and children.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016Article
- Antihistamines prescribed off-label among paediatric patients at a tertiary care hospital setting in Malaysia.International journal of clinical pharmacy · 2016Observational
- Off-label prescribing for allergic diseases in children.The World Allergy Organization journal · 2014Article
- Incidence of unlicensed and off-label prescription in children.Italian journal of pediatrics · 2014Article
- Unlicensed and off-label use of medicines in children admitted to the intensive care units of a hospital in Malaysia.International journal of clinical pharmacy · 2013Observational
- Evaluation of Off-label Prescribing at a Children's Rehabilitation Center.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective of the studyTo determine the extent and nature of unlicensed/off-label prescribing patterns in hospitalised children in Palestine.
settingFour paediatric wards in two public health system hospitals in Palestine [Caritas children's hospital (Medical and neonatal intensive care units) and Rafidia general hospital (Medical and surgical units)].
methodA prospective survey of drugs administered to infants and children <18 years old was carried out over a five-week period in the four paediatric wards.
main outcome measureDrug-licensing status of all prescriptions was determined according to the Palestinian Registered Product List and the Physician's Desk Reference.
resultsOverall, 917 drug prescriptions were administered to 387children. Of all drug prescriptions, 528 (57.5%) were licensed for use in children; 65 (7.1%) were unlicensed; and 324 (35.3%) were used off-label. Of all children, 49.6% received off-label prescriptions, 10.1% received unlicensed medications and 8.2% received both. Seventy-two percent of off-label drugs and 66% of unlicensed drugs were prescribed for children <2 years. Multivariate analysis showed that patients who were admitted to the neonatal intensive care unit and infants aged 0-1 years were most likely to receive a greater number of off-label or unlicensed medications (OR 1.80; 95% CI 1.03-3.59 and OR 1.99; 95% CI 0.88-3.73, respectively).
conclusionThe present findings confirmed the elevated prevalence of unlicensed and off-label paediatric drugs use in Palestine and strongly support the need to perform well designed clinical studies in children.
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Registered trials
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