ArticleIntensive care medicine2011
Role of distinct phospholipases A2 and their modulators in meconium aspiration syndrome in human neonates.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Evidence certainty in neonatology-a meta-epidemiological analysis of Cochrane reviews.European journal of pediatrics · 2025Pooled it
- Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study.BMC pediatrics · 2011Trial
- Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Sex differences in vanadium inhalation effects in non-ciliated bronchiolar cells.Histology and histopathology · 2023Article
- Factors associated with SARS-CoV-2 transplacental transmission.American journal of obstetrics and gynecology · 2022Article
- Strategies to protect surfactant and enhance its activity.Biomedical journal · 2021Review
- The International Week of Surfactant Research: Increasing knowledge about surfactant and unexploited opportunities.Biomedical journal · 2021Article
- Recombinant Human Superoxide Dismutase andMolecules (Basel, Switzerland) · 2019Article
- Controlled hypothermia may improve surfactant function in asphyxiated neonates with or without meconium aspiration syndrome.PloS one · 2018Article
- Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).Expert opinion on therapeutic targets · 2016Review
- Meconium-induced inflammation and surfactant inactivation: specifics of molecular mechanisms.Pediatric research · 2016Review
- Morphologic Damage of Rat Alveolar Epithelial Type II Cells Induced by Bile Acids Could Be Ameliorated by Farnesoid X Receptor Inhibitor Z-Guggulsterone In Vitro.BioMed research international · 2016Article
- Secreted phospholipase A2 is increased in meconium-stained amniotic fluid of term gestations: potential implications for the genesis of meconium aspiration syndrome.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014Article
- Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis.Journal of molecular medicine (Berlin, Germany) · 2014Article
- Effect of bile Acid on fetal lung in rat model of intrahepatic cholestasis of pregnancy.International journal of endocrinology · 2014Article
- Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants.Critical care (London, England) · 2013Article
- Year in review in Intensive Care Medicine 2011: III. ARDS and ECMO, weaning, mechanical ventilation, noninvasive ventilation, pediatrics and miscellanea.Intensive care medicine · 2012Review
- Meconium Influences Pulmonary Short-Chain Fatty Acid Concentration in Porcine Meconium Aspiration Model.Biomedicine hubArticle
- Quantitative lung ultrasound to understand pathophysiology and guide surfactant therapy in neonates with meconium aspiration.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMeconium aspiration syndrome (MAS) is a life-threatening neonatal lung injury, whose pathophysiology has been mainly studied in animal models. In such models, pancreatic secretory phospholipase A2 (sPLA2-IB) and proinflammatory cytokines present in meconium challenge the lungs, catabolising surfactant and harming the alveoli. Locally produced phospholipases might perpetuate the injury and influence clinical pictures and therapeutic approaches. Our aim is to verify whether pulmonary phospholipase A2 (sPLA2-IIA) is involved in the damage and to determine if phospholipases and their modulators are associated with MAS clinical pictures.
methodsWe studied distinct phospholipases A2 and their modulators in broncho-alveolar lavage (BAL) fluids and in meconium of five MAS neonates and in five control neonates ventilated for extrapulmonary reasons.
resultsMAS patients have higher amounts of pulmonary phospholipase (sPLA2-IIA; P = 0.016) and Clara cell secretory protein (CCSP; P = 0.032). The local production of such proteins by the lung is confirmed by their very low levels in meconium. sPLA2-IIA contributes to the higher total enzyme activity in MAS patients, as compared to controls (P = 0.008). Cytosolic phospholipase was not detected in meconium or alveolar fluid. sPLA2 activity and sPLA2-IIA concentrations are correlated with the TNFα and with the release of CCSP. sPLA2 total activity, sPLA2-IIA and TNFα concentrations in BAL fluids correlate with the oxygenation impairment and haemorrhagic lung oedema.
conclusionsPulmonary sPLA2 is locally produced and contributes to the total sPLA2 activity during MAS. CCSP is also produced in trying to lower the inflammation. Both sPLA2 activity and sPLA2-IIA are significantly correlated with oxygenation impairment and haemorrhagic lung oedema.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.