ArticleInternational journal of preventive medicine2010
Outcome of congenitally hypothyroid screening program in isfahan: iran from prevention to treatment.
Article in International journal of preventive medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Trend of Congenital Hypothyroidism Incidence and Its Affecting Factors in Shahr-e-Kord, Western Iran.Iranian journal of public health · 2020Article
- Congenital hypothyroidism in different cities of the Isfahan province: A descriptive retrospective study.Journal of education and health promotion · 2019Article
- Article
- Worldwide Recall Rate in Newborn Screening Programs for Congenital Hypothyroidism.International journal of endocrinology and metabolism · 2017Review
- Congenital hypothyroidism screening program in iran; a systematic review and metaanalysis.Iranian journal of pediatrics · 2014Review
- Prevalence of permanent congenital hypothyroidism in isfahan-iran.International journal of preventive medicine · 2013Article
- Prevalence of transient congenital hypothyroidism in central part of Iran.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- The role of ultrasonography in primary congenital hypothyroidism.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEarly and proper treatment is crucial to prevent neuropsychologic deficits in congenital hypothyroidism (CH). Considering the high prevalence of CH in Isfahan, the aim of this study was to evaluate the outcome of treatment in CH patients.
methodsIn this study CH neonates diagnosed during screening program in Isfahan from May 2002 to September 2009 were studied. Frequent visits were performed to CH patients to monitor and follow their treatments. Quality of treatment was assessed by evaluating mean age of treatment initiation and mean TSH and T4 levels before and after treatment and during the first and second years according to their normal reference ranges.
resultsOf 225,224 screened neonates, 536 were diagnosed as CH patients. The prevalence of CH was 1/420 live births. Mean age at starting treatment was 22.9 ± 13.2 days. In 93.7% of patients, treatment was begun before the 45th day of life. In the first measurement after initiating the treatment, T4 and TSH were not in their acceptable range in 3.9% and 9.8% of CH patients, respectively. Mean T4 and TSH reached to normal range during the treatment period. T4 reached the normal range earlier than TSH.
conclusionsThe mean age of treatment initiation was in acceptable range but the findings suggest that both early and high-dose treatments are crucial for optimal treatment, especially in patients with severe CH. Further studies are needed to determine the outcome of treatment specially regarding to different etiologies of CH.
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21566768PMC3075477W1572406026What OpenQuestion holds
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