ArticleJournal of perinatology : official journal of the California Perinatal Association2012
Fulminant necrotizing enterocolitis in a multihospital healthcare system.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Erythropoietin prevents necrotizing enterocolitis in very preterm infants: a randomized controlled trial.Journal of translational medicine · 2020Trial
- Diagnosis and Staging of Necrotizing Enterocolitis: Current Controversies and a Phenotype-Based Framework.Children (Basel, Switzerland) · 2026Review
- A case-control study of necrotising enterocolitis in very low birth weight neonates at a tertiary hospital in South Africa.Frontiers in pediatrics · 2026Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Assessment of inflammatory biomarkers to identify surgical/death necrotizing enterocolitis in preterm infants without pneumoperitoneum.Pediatric surgery international · 2024Article
- Clinical Correlates of Moderate-to-Severe Bronchopulmonary Dysplasia in Preterm Infants following Surgical Necrotizing Enterocolitis.American journal of perinatology · 2024Article
- Do hematological biomarkers predict surgical necrotizing enterocolitis?Pediatric research · 2024Article
- Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis.Pediatric research · 2024Article
- Outcomes by disease onset, sex, and intervention in neonates with SIP and surgical NEC.Pediatric research · 2024Article
- Risk factors for postoperative complications in preterm infants with surgical necrotizing enterocolitis and associated outcomes.Journal of neonatal-perinatal medicine · 2024Article
- Postoperative Outcomes, and Growth and Brain Injury Outcomes in Spontaneous Intestinal Perforation vs Surgical Necrotizing Enterocolitis in Preterm Infants.Indian pediatrics · 2023Article
- Investigation of biomarkers in a rare case of fulminant necrotizing enterocolitis in a preterm infant.Fukushima journal of medical science · 2023Article
- Nomogram for predicting fulminant necrotizing enterocolitis.Pediatric surgery international · 2023Article
- Clinical determinants of intestinal failure and death in preterm infants with surgical necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2023Article
- Machine learning-based risk factor analysis of necrotizing enterocolitis in very low birth weight infants.Scientific reports · 2022Article
- Clinical impact of severe acute kidney injury on post-operative and brain injury outcomes in preterm infants following surgical necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Gestational age-specific hematological patterns in preterm infants following necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Predictive factors for rapid progression in preterm neonates with necrotizing enterocolitis.Frontiers in pediatrics · 2022Article
- Framework for feature selection of predicting the diagnosis and prognosis of necrotizing enterocolitis.PloS one · 2022Article
- Hematological predictors of mortality in neonates with fulminant necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA subset of necrotizing enterocolitis (NEC) cases is fulminant, characterized by rapid progression to death with massive bowel necrosis found at laparotomy or autopsy. We sought to identify and report all such cases in a multihospital healthcare system during the past 9 years and to characterize this entity using case-control methodologies. STUDY
designThis was a multicentered, cross-sectional, historic cohort study conducted using Intermountain Healthcare hospital patient data. All neonates who died of NEC within 48 h of onset, during 2001 to 2009, were compared with two matched control groups: (1) demographically matched controls who developed non-fulminant NEC, (2) demographically matched controls that did not develop NEC.
resultDuring this period, 2 71 327 live births occurred in the Intermountain Healthcare hospitals. Of these, 318 had a diagnosis of NEC (Bell stage ≥II). Also during this period, 205 other neonates were transferred into an Intermountain hospital for treatment of NEC. Of these 523 NEC cases, 35 (6.7%) had a fulminant course. Compared with the non-fulminant cases, the fulminant group were born at lower weight (1088±545 vs 1652±817 g, P=0.000) and earlier gestational age (27.5±3.3 vs 31.1±4.4 weeks, P=0.000), and were more likely to have: (1) radiographic evidence of portal venous air (P=0.000), (2) hematocrit <22% (P=0.000), (3) increase in feeding volume >20 ml/kg/day (P=0.003), (4) immature to total (I/T) neutrophil ratio >0.5 (P=0.005), (5) blood lymphocyte count <4000/μl (P=0.018), (6) an increase in concentration of human milk fortifier within 48 h before developing NEC (P=0.020).
conclusionPortal venous air, anemia, rapid feeding escalation, a high I/T neutrophil ratio, a low lymphocyte count and recent increases in fortifier may all be associated with fulminant NEC.
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