Interference between PARPs and SIRT1: a novel approach to healthy ageing?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

27 citing papers in PubMed.

1. Oxidative Stress, Environmental Pollutants, Aging, and Epigenetic Regulation: Mechanistic Insights and Biomarker Advances.Antioxidants (Basel, Switzerland) · 2026
   Review
2. Interaction between Poly(ADP-ribose) polymerase-1 and α-synuclein pathology in Parkinson's disease.Frontiers in neuroscience · 2026
   Review
3. The Role of NAD+, SIRTs Interactions in Stimulating and Counteracting Carcinogenesis.International journal of molecular sciences · 2023
   Review
4. The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation.International journal of molecular sciences · 2023
   Review
5. eNAMPT actions through nucleus accumbens NADScience advances · 2022
   Article
6. Changes in Stress-Mediated Markers in a Human Cardiomyocyte Cell Line under Hyperglycemia.International journal of molecular sciences · 2021
   Article
7. Molecular Mechanisms of Intermittent Fasting-induced Ischemic Tolerance.Conditioning medicine · 2020
   Article
8. The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020
   Article
9. Role of endothelial NADAmerican journal of physiology. Heart and circulatory physiology · 2019
   Review
10. Cancer Etiology: A Metabolic Disease Originating from Life's Major Evolutionary Transition?Oxidative medicine and cellular longevity · 2019
    Review
11. SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model.Molecular neurobiology · 2018
    Article
12. PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance.PLoS pathogens · 2018
    Article
13. Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi.Infection and immunity · 2016
    Article
14. SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair.The EMBO journal · 2016
    Article
15. Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease.The American journal of pathology · 2016
    Article
16. MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis.Journal of cellular and molecular medicine · 2015
    Review
17. The Molecular Circadian Clock and Alcohol-Induced Liver Injury.Biomolecules · 2015
    Review
18. Mitochondrial dysfunction in cancer.Frontiers in oncology · 2013
    Review
19. Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Molecular aspects of medicine · 2013
    Review
20. Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle.Longevity & healthspan · 2013
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

Abstract

Indexed as