Evidence map›Paper›PMID 21566257›Full record

ReviewAging2011

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective.

Alessandra Valerio, Giuseppe D'Antona, Enzo Nisoli

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05143398 (Effectiveness of a Rehabilitation Program), which is not on this map. Cited by 86 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05143398 nacompletednot on this mapstarted 2018, after this paper: background citation

Effectiveness of a Rehabilitation Program (Nutritional + Physical Activity) in Sarcopenic Obesity

TypeinterventionalSponsorIstituto Auxologico ItalianoRan2018 to 2021Enrolled80ConditionsSarcopenic ObesityArmsDiet + protein, Diet + EAA, Diet + EAA and TCA, Diet
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 200 citations in OpenAlex.

  1. Pooled it
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  3. Metabolomic profiles of being physically active and less sedentary: a critical review.Metabolomics : Official journal of the Metabolomic Society · 2021
    Pooled it
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  11. A seven-year longitudinal study of the Alzheimer's disease blood metabolome.medRxiv : the preprint server for health sciences · 2025
    Article
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  15. Review
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Alessandra ValerioPharmacology Unit, Department of Biomedical Sciences and Biotechnologies, Brescia University, Italy.
Giuseppe D'Antona
Enzo Nisoli
University of Brescia · ITUniversity of Milan · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary regimen with adequate nutrition) slows the progression of age-related diseases and extends the lifespan of many species. Identification of strategies mimicking key CR mechanisms - increased mitochondrial respiration and reduced production of oxygen radicals - is a hot topic in gerontology. Dietary supplementation with essential and/or branched chain amino acids (BCAAs) exerts a variety of beneficial effects in experimental animals and humans and has been recently demonstrated to support cardiac and skeletal muscle mitochondrial biogenesis, prevent oxidative damage, and enhance physical endurance in middle-aged mice, resulting in prolonged survival. Here we review recent studies addressing the possible role of BCAAs in energy metabolism and in the longevity of species ranging from unicellular organisms to mammals. We also summarize observations from human studies supporting the exciting hypothesis that dietary BCAA enriched mixture supplementation might be a health-promoting strategy in aged patients at risk.

Indexed as

Biological EvolutionAmino Acids, Branched-ChainAnimalsCaloric RestrictionDietDietary SupplementsEnergy MetabolismHumansLongevityMitochondriaNutritional StatusAmino Acids, Branched-Chain

Identifiers

PMID21566257
PMCPMC3156598
OpenAlexW1598035363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.