ArticleStroke2011
Elderly women regulate brain blood flow better than men do.
Article in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Does Gender Influence the Relationship Between High Blood Pressure and Dementia? Highlighting Areas for Further Investigation.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Sex differences in dynamic cerebral autoregulation responses to resistance and endurance training in humans.Experimental physiology · 2026Article
- Near-lifespan mesoscopic optical imaging of cerebrovascular function reveals age and sex differences in preclinical Alzheimer's disease model.Brain communications · 2025Article
- Brain-body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis.Nature reviews. Neurology · 2024Review
- Cerebrovascular responses to a 90° tilt in healthy neonates.Pediatric research · 2024Article
- The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- The utility of therapeutic hypothermia on cerebral autoregulation.Journal of intensive medicine · 2023Review
- Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease.Pediatric cardiology · 2022Article
- Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men.GeroScience · 2022Article
- Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Increased multimorbidity is associated with impaired cerebral and peripheral hemodynamic stabilization during active standing.Journal of the American Geriatrics Society · 2022Article
- The impact of age, sex, cardio-respiratory fitness, and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity.European journal of applied physiology · 2022Article
- Machine Learning Models and Statistical Complexity to Analyze the Effects of Posture on Cerebral Hemodynamics.Entropy (Basel, Switzerland) · 2022Article
- Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide.Frontiers in aging neuroscience · 2022Article
- Cerebral critical closing pressure and resistance-area product: the influence of dynamic cerebral autoregulation, age and sex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Sex differences in the association between major cardiovascular risk factors in midlife and dementia: a cohort study using data from the UK Biobank.BMC medicine · 2021Article
- Cerebral Autoregulation in Ischemic Stroke: From Pathophysiology to Clinical Concepts.Brain sciences · 2021Review
- Integrative cardiovascular control in women: Regulation of blood pressure, body temperature, and cerebrovascular responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeOrthostatic intolerance and falls differ between sexes and change with age. However, it remains unclear what role cerebral autoregulation may play in this response. This study was designed to determine whether cerebral autoregulation, assessed using transcranial Doppler ultrasound, is more effective in elderly females than in males.
methodsWe used transcranial Doppler ultrasound to evaluate cerebral autoregulation in 544 (236 male) subjects older than age 70 years recruited as part of the MOBILIZE Boston study. The MOBILIZE Boston study is a prospective cohort study of a unique set of risk factors for falls in seniors in the Boston area. We assessed CO2 reactivity and transfer function gain, phase, and coherence during 5 minutes of quiet sitting and autoregulatory index during sit-to-stand tests.
resultsMale subjects had significantly lower CO2 reactivity (males, 1.10 ± 0.03; females, 1.32 ± 0.43 (cm/s)/%CO2; P<0.001) and autoregulatory indices (males, 4.41 ± 2.44; female, 5.32 ± 2.47; P<0.001), higher transfer function gain (males, 1.34 ± 0.49; females, 1.19 ± 0.43; P=0.002), and lower phase (males, 42.7 ± 23.6; females, 49.4 ± 24.9; P=0.002) in the autoregulatory band, implying less effective cerebral autoregulation. However, reduced autoregulation in males was not below the normal range, indicating autoregulation was intact but less effective.
conclusionsFemale subjects were better able to maintain cerebral flow velocities during postural changes and demonstrated better cerebral autoregulation. The mechanisms of sex-based differences in autoregulation remain unclear but may partially explain the higher rates of orthostatic hypotension-related hospitalizations in elderly men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.