ReviewThe Journal of biological chemistry2011
Extending biochemical databases by metabolomic surveys.
Review in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis.Alimentary pharmacology & therapeutics · 2014Trial
- Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy.PloS one · 2013Trial
- Global omics study of Tetraselmis chuii reveals time-related metabolic adaptations upon oxidative stress.Applied microbiology and biotechnology · 2024Article
- Metabolic Aspects of Lentil-Plants (Basel, Switzerland) · 2024Article
- Selenium-binding Protein 1 (SBD1): A stress response regulator in Chlamydomonas reinhardtii.Plant physiology · 2022Article
- Characterization of intestinal microbiota and serum metabolites in patients with mild hepatic encephalopathy.Open life sciences · 2022Article
- Approaches for completing metabolic networks through metabolite damage and repair discovery.Current opinion in systems biology · 2021Review
- The Development of Bacteriophage Resistance inViruses · 2021Article
- Data Processing Thresholds for Abundance and Sparsity and Missed Biological Insights in an Untargeted Chemical Analysis of Blood Specimens for Exposomics.Frontiers in public health · 2021Article
- Chemical Discovery in the Era of Metabolomics.Journal of the American Chemical Society · 2020Review
- Current Practice in Untargeted Human Milk Metabolomics.Metabolites · 2020Review
- METLIN: A Tandem Mass Spectral Library of Standards.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Metabolomics: A Way Forward for Crop Improvement.Metabolites · 2019Review
- Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.Cell metabolism · 2019Article
- Serum and urinary metabolomics and outcomes in cirrhosis.PloS one · 2019Article
- Combined network analysis and machine learning allows the prediction of metabolic pathways from tomato metabolomics data.Communications biology · 2019Article
- Chemical Similarity Enrichment Analysis (ChemRICH) as alternative to biochemical pathway mapping for metabolomic datasets.Scientific reports · 2017Article
- Global open data management in metabolomics.Current opinion in chemical biology · 2017Review
- Rifaximin Exerts Beneficial Effects Independent of its Ability to Alter Microbiota Composition.Clinical and translational gastroenterology · 2016Article
- A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.Nature chemical biology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics can map the large metabolic diversity in species, organs, or cell types. In addition to gains in enzyme specificity, many enzymes have retained substrate and reaction promiscuity. Enzyme promiscuity and the large number of enzymes with unknown enzyme function may explain the presence of a plethora of unidentified compounds in metabolomic studies. Cataloguing the identity and differential abundance of all detectable metabolites in metabolomic repositories may detail which compounds and pathways contribute to vital biological functions. The current status in metabolic databases is reviewed concomitant with tools to map and visualize the metabolome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.