Evidence map›Paper›PMID 21566119›Full record

ReviewThe Journal of biological chemistry2011

Advancing science through mining libraries, ontologies, and communities.

James A Evans, Andrey Rzhetsky

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Text mining applications in psychiatry: a systematic literature review.International journal of methods in psychiatric research · 2016
    Pooled it
  2. Review
  3. Article
  4. Predicting research trends with semantic and neural networks with an application in quantum physics.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. Article
  6. MOLIERE: Automatic Biomedical Hypothesis Generation System.KDD : proceedings. International Conference on Knowledge Discovery & Data Mining · 2017
    Article
  7. Article
  8. A knowledge base of vasopressin actions in the kidney.American journal of physiology. Renal physiology · 2014
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James A EvansDepartment of Sociology, University of Chicago, Chicago, Illinois 60637, USA. jevans@uchicago.edu
Andrey Rzhetsky

Funding

Computer Systems for Functional Analysis of Genomic DataR01GM061372 · NIGMS · UNIVERSITY OF CHICAGO · PI RZHETSKY, ANDREY · 2001 to 2009
$2.8M
Large-scale Discovery of Scientific Hypotheses; Computation Over Expert OpinionsR01LM010132 · NLM · UNIVERSITY OF CHICAGO · PI EVANS, JAMES ALLEN, FOSTER, IAN · 2009 to 2010
$1.2M
NIGMS NIH HHS R01 GM061372NLM NIH HHS R01 LM010132
6 · The paper itself

Abstract

Life scientists today cannot hope to read everything relevant to their research. Emerging text-mining tools can help by identifying topics and distilling statements from books and articles with increased accuracy. Researchers often organize these statements into ontologies, consistent systems of reality claims. Like scientific thinking and interchange, however, text-mined information (even when accurately captured) is complex, redundant, sometimes incoherent, and often contradictory: it is rooted in a mixture of only partially consistent ontologies. We review work that models scientific reason and suggest how computational reasoning across ontologies and the broader distribution of textual statements can assess the certainty of statements and the process by which statements become certain. With the emergence of digitized data regarding networks of scientific authorship, institutions, and resources, we explore the possibility of accounting for social dependences and cultural biases in reasoning models. Computational reasoning is starting to fill out ontologies and flag internal inconsistencies in several areas of bioscience. In the not too distant future, scientists may be able to use statements and rich models of the processes that produced them to identify underexplored areas, resurrect forgotten findings and ideas, deconvolute the spaghetti of underlying ontologies, and synthesize novel knowledge and hypotheses.

Indexed as

Models, BiologicalAnimalsComputational BiologyHumans

Identifiers

PMID21566119
PMCPMC3129146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.