ArticleMicrobiology (Reading, England)2011
Differential response of Streptococcus mutans towards friend and foe in mixed-species cultures.
Article in Microbiology (Reading, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Evaluation of Streptococcus mutans strains possessing genes encoding collagen-binding proteins in the Japanese population.BMC oral health · 2025Article
- Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome.ACS central science · 2025Article
- Identification ofmBio · 2024Article
- Stability of the Dentin-Bonded Interface Using Self-Etching Adhesive Containing Diacrylamide after Bacterial Challenge.ACS applied materials & interfaces · 2024Article
- Bacterial dynamics in the progression of caries to apical periodontitis in primary teeth of children with severe early childhood caries.Frontiers in microbiology · 2024Article
- In Vitro Synergistic Antibacterial Effects of Extract and Honey Derived from Nigella Sativa on Streptococcus Mutans : Antibacterial Effects of Nigella Sativa Extract and Honey.Galen medical journal · 2024Article
- Social networking at the microbiome-host interface.Infection and immunity · 2023Review
- Effects of Tea Polyphenols and Theaflavins on Three Oral Cariogenic Bacteria.Molecules (Basel, Switzerland) · 2023Article
- Growth with Commensal Streptococci AltersJournal of dental research · 2023Article
- Copper ions inhibit Streptococcus mutans-Veillonella parvula dual biofilm by activating Streptococcus mutans reactive nitrogen species.BMC oral health · 2023Article
- Oral Commensal Streptococci: Gatekeepers of the Oral Cavity.Journal of bacteriology · 2022Review
- A comprehensive review of the antibacterial activity of dimethylaminohexadecyl methacrylate (DMAHDM) and its influence on mechanical properties of resin-based dental materials.The Japanese dental science review · 2021Review
- High Counts and Anthracene Degradation Ability ofFrontiers in microbiology · 2021Article
- Oral Dysbiosis and Inflammation in Parkinson's Disease.Journal of Parkinson's disease · 2021Article
- [Research progress in the relationship between Veillonella and oral diseases].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Review
- Use of an oxygen planar optode to assess the effect of high velocity microsprays on oxygen penetration in a human dental biofilms in-vitro.BMC oral health · 2020Article
- Interaction variability shapes succession of synthetic microbial ecosystems.Nature communications · 2020Article
- Transcriptional profiling of coaggregation interactions between Streptococcus gordonii and Veillonella parvula by Dual RNA-Seq.Scientific reports · 2019Article
- Short-Time Antibacterial Effects of Dimethylaminododecyl Methacrylate on Oral Multispecies Biofilm In Vitro.BioMed research international · 2019Article
- Novel dental composite with capability to suppress cariogenic species and promote non-cariogenic species in oral biofilms.Materials science & engineering. C, Materials for biological applications · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In the oral biofilm, the 'mitis' streptococci are among the first group of organisms to colonize the tooth surface. Their proliferation is thought to be an important factor required for antagonizing the growth of cariogenic species such as Streptococcus mutans. In this study, we used a three-species mixed culture to demonstrate that another ubiquitous early colonizing species, Veillonella parvula, can greatly affect the outcome of the competition between a pair of antagonists such as S. mutans and Streptococcus gordonii. Transcriptome analysis further revealed that S. mutans responds differentially to its friend (V. parvula) and foe (S. gordonii). In the mixed culture with S. gordonii, all but one of the S. mutans sugar uptake and metabolic genes were downregulated, while genes for alternative energy source utilization and H₂O₂ tolerance were upregulated, resulting in a slower but persistent growth. In contrast, when cultured with V. parvula, S. mutans grew equally well or better than in monoculture and exhibited relatively few changes within its transcriptome. When V. parvula was introduced into the mixed culture of S. mutans and S. gordonii, it rescued the growth inhibition of S. mutans. In this three-species environment, S. mutans increased the expression of genes required for the uptake and metabolism of minor sugars, while genes required for oxidative stress tolerance were downregulated. We conclude that the major factors that affect the competition between S. mutans and S. gordonii are carbohydrate utilization and H₂O₂ resistance. The presence of V. parvula in the tri-species culture mitigates these two major factors and allows S. mutans to proliferate, despite the presence of S. gordonii.
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