Trial reportHaematologica2011
Central nervous system involvement at first relapse in patients with acute myeloid leukemia.
Trial report in Haematologica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Factors associated with risk of central nervous system relapse in patients with non-core binding factor acute myeloid leukemia.American journal of hematology · 2017Trial
- MSLN expression predicts a high risk of EMD in AML by promoting cell adhesion and metastasis via interaction with MUC16.Blood advances · 2026Article
- Case Report: Central nervous system infiltration after allogeneic hematopoietic stem cell transplantation in high-risk myelodysplastic neoplasms.Frontiers in oncology · 2026Article
- Second Allogeneic Stem Cell Transplantation in an inv16 Patient with Acute Myeloid Leukemia and Isolated Central Nervous System Relapse in the Form of Pituitary AdenomaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Isolated central nervous system relapse in acute myeloid leukemia: a case report and review of therapeutic challenges.Frontiers in oncology · 2025Article
- Effects of Total Body Irradiation on Hematopoietic Cell Transplantation Outcomes in Pediatric Acute Myeloid Leukemia with Prior Central Nervous System Involvement.Transplantation and cellular therapy · 2024Article
- Central Nervous System Prophylaxis and Treatment in Acute Leukemias.Current treatment options in oncology · 2022Review
- Central Nervous System Involvement in Adults with Acute Leukemia: Diagnosis, Prevention, and Management.Current oncology reports · 2022Review
- A narrative review of central nervous system involvement in acute leukemias.Annals of translational medicine · 2021Review
- Optic neuropathy as the first sign of central nervous system relapse in acute myeloid leukaemia: MRI findings and its diagnostic challenge.BMJ case reports · 2019Article
- Symptomatic central nervous system involvement in adult patients with acute myeloid leukemia.Cancer management and research · 2017Article
- Clinical outcome and efficacy of current anti-leukemic therapy for leptomeningeal involvement in acute myeloid leukemia.International journal of hematology · 2016Article
- Incidence of and risk factors for involvement of the central nervous system in acute myeloid leukemia.Leukemia & lymphoma · 2015Article
- Pseudo-Guillain-Barré syndrome masking acute myeloid leukemia relapse: Brief report and review.Leukemia research reports · 2015Article
- Strabismus and diplopia in a patient with acute myeloid leukemia.The American journal of case reports · 2014Article
- New agents for the treatment of lymphoid leukemia and lymphoma: focus on recent FDA approvals.Discoveries (Craiova, Romania)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk factors for and incidence of central nervous system involvement at first relapse in adult patients with acute myeloid leukemia have not been established. This single-center study analyzed the prognostic factors for and cumulative incidence of meningeal relapse in 458 adult patients achieving complete remission. Before 1990, patients received old chemotherapy approaches without stem cell transplantation that often included prophylactic intrathecal chemotherapy. Since 1990, modern protocols included stem cell transplantation without intrathecal prophylaxis. Meningeal relapse occurred in 6 patients (overall 5-year cumulative incidence 1.3%). The 5-year cumulative incidence of meningeal relapse in patients treated with old and modern protocols were 3.9% and 0.3%, respectively. Univariate and multivariate analyses showed that the chemotherapy approach was the main prognostic factor for central nervous system relapse (P=0.02). This study shows an extremely low incidence of meningeal relapse in adult patients with acute myeloid leukemia treated with modern protocols including stem cell transplantation without intrathecal prophylaxis.
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