ArticleStructure (London, England : 1993)2011
X-ray crystallography and isothermal titration calorimetry studies of the Salmonella zinc transporter ZntB.
Article in Structure (London, England : 1993), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A flow equilibrium model controlling cytoplasmic transition metal cation pools and preventing mis-metalation as exemplified for zinc homeostasis.Journal of bacteriology · 2025Review
- Cation permeability in CorA family of proteins.Scientific reports · 2020Article
- Resistance to Metals Used in Agricultural Production.Microbiology spectrum · 2018Review
- The structural basis of proton driven zinc transport by ZntB.Nature communications · 2017Article
- Zinc stress induces copper depletion in Acinetobacter baumannii.BMC microbiology · 2017Article
- Critical Issues in the Study of Magnesium Transport Systems and Magnesium Deficiency Symptoms in Plants.International journal of molecular sciences · 2015Review
- Isothermal titration calorimetry of ion-coupled membrane transporters.Methods (San Diego, Calif.) · 2015Article
- Metalloregulation of Helicobacter pylori physiology and pathogenesis.Frontiers in microbiology · 2015Review
- Evolution of the genetic code by incorporation of amino acids that improved or changed protein function.Journal of molecular evolution · 2013Article
- Contributions of five secondary metal uptake systems to metal homeostasis of Cupriavidus metallidurans CH34.Journal of bacteriology · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The ZntB Zn(2+) efflux system is important for maintenance of Zn(2+) homeostasis in Enterobacteria. We report crystal structures of ZntB cytoplasmic domains from Salmonella enterica serovar Typhimurium (StZntB) in dimeric and physiologically relevant homopentameric forms at 2.3 Å and 3.1 Å resolutions, respectively. The funnel-like structure is similar to that of the homologous Thermotoga maritima CorA Mg(2+) channel and a Vibrio parahaemolyticus ZntB (VpZntB) soluble domain structure. However, the central α7 helix forming the inner wall of the StZntB funnel is oriented perpendicular to the membrane instead of the marked angle seen in CorA or VpZntB. Consequently, the StZntB funnel pore is cylindrical, not tapered, which may represent an "open" form of the ZntB soluble domain. Our crystal structures and isothermal titration calorimetry data indicate that there are three Zn(2+) binding sites in the full-length ZntB, two of which could be involved in Zn(2+) transport.
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Registered trials
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