ArticleStructure (London, England : 1993)2011
Atomic model of CPV reveals the mechanism used by this single-shelled virus to economically carry out functions conserved in multishelled reoviruses.
Article in Structure (London, England : 1993), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
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- Integration of Cypoviruses into polyhedrin matrix.Nanoscale advances · 2023Article
- Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation.Protein & cell · 2023Article
- The structure of a 12-segmented dsRNA reovirus: New insights into capsid stabilization and organization.PLoS pathogens · 2023Article
- Multiple conformations of trimeric spikes visualized on a non-enveloped virus.Nature communications · 2022Article
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- Mechanisms of Cell Entry by dsRNA Viruses: Insights for Efficient Delivery of dsRNA and Tools for Improved RNAi-Based Pest Control.Frontiers in physiology · 2021Review
- Transcriptional response of immune-related genes after endogenous expression of VP1 and exogenous exposure to VP1-based VLPs and CPV virions in lepidopteran cell lines.Molecular genetics and genomics : MGG · 2019Article
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- A fragment based method for modeling of protein segments into cryo-EM density maps.BMC bioinformatics · 2017Article
- Cypovirus capsid protein VP5 has nucleoside triphosphatase activity.Virologica Sinica · 2017Article
- A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM.Structure (London, England : 1993) · 2017Article
- MTase Domain of Dendrolimus punctatus cypovirus VP3 Mediates Virion Attachment and Interacts with Host ALP Protein.Viruses · 2017Article
- Structural analysis and insertion study reveal the ideal sites for surface displaying foreign peptides on a betanodavirus-like particle.Veterinary research · 2016Article
- Exploring the inside details of virions by electron microscopy.Biophysics reports · 2016Article
- In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus.Nature · 2015Article
- Article
- 2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor.Science (New York, N.Y.) · 2015Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Unlike the multishelled viruses in the Reoviridae, cytoplasmic polyhedrosis virus (CPV) is single shelled, yet stable and fully capable of carrying out functions conserved within Reoviridae. Here, we report a 3.1 Å resolution cryo electron microscopy structure of CPV and derive its atomic model, consisting of 60 turret proteins (TPs), 120 each of capsid shell proteins (CSPs) and large protrusion proteins (LPPs). Two unique segments of CSP contribute to CPV's stability: an inserted protrusion domain interacting with neighboring proteins, and an N-anchor tying up CSPs together through strong interactions such as β sheet augmentation. Without the need to interact with outer shell proteins, LPP retains only the N-terminal two-third region containing a conserved helix-barrel core and interacts exclusively with CSP. TP is also simplified, containing only domains involved in RNA capping. Our results illustrate how CPV proteins have evolved in a coordinative manner to economically carry out their conserved functions.
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