ArticleCell2011
Metabolic homeostasis: HDACs take center stage.
Article in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Dissecting the epigenetic orchestra of HDAC isoforms in breast cancer development: a review.Medical oncology (Northwood, London, England) · 2024Review
- Targeting HDACs for diffuse large B-cell lymphoma therapy.Scientific reports · 2024Article
- Combined In Silico and In Vitro Analyses to Assess the Anticancer Potential of Thiazolidinedione-Thiosemicarbazone Hybrid Molecules.International journal of molecular sciences · 2023Article
- A Longitudinal Study of the Association between theInternational journal of molecular sciences · 2022Article
- Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology Perspective.Metabolites · 2021Review
- Review
- Review
- Curcumin ameliorates gestational diabetes in mice partly through activating AMPK.Pharmaceutical biology · 2019Article
- The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model.Molecular & cellular proteomics : MCP · 2017Article
- HDAC Inhibitor Conjugated Polymeric Prodrug Micelles for Doxorubicin Delivery.Journal of materials chemistry. B · 2017Article
- A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.The pharmacogenomics journal · 2017Article
- Compartmentation of metabolites in regulating epigenome of cancer.Molecular medicine (Cambridge, Mass.) · 2016Article
- Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed.Future medicinal chemistry · 2012Review
- Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening.Assay and drug development technologiesArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Hormonal regulation of glucose and lipid metabolism is pivotal for metabolic homeostasis and energy balance. Two studies in this issue of Cell (Mihaylova et al., 2011 and Wang et al., 2011) introduce a new conserved signaling mechanism controlling catabolic gene expression: class IIa histone deacetylases (HDACs) regulate Foxo activity in Drosophila and mice.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.