ArticleClinical immunology (Orlando, Fla.)2011
Thymic microenvironment reconstitution after postnatal human thymus transplantation.
Article in Clinical immunology (Orlando, Fla.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase II Study of Thymus Transplantation in Complete DiGeorge Syndrome #668
Dose Study of Thymus Transplantation in DiGeorge Anomaly, IND 9836, #932.1
Phase I/II Trial of Thymus Transplantation With Immunosuppression, #950
Safety and Efficacy of Thymus Transplantation in Complete DiGeorge Anomaly, IND#9836
Expanded Access Protocol Thymus Transplantation for Immunodeficiency, Hematologic Malignancies, and Autoimmune Disease Related to Poor Thymic Function
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Thymus transplantation for DiGeorge Syndrome: a systematic review.Pediatric surgery international · 2025Pooled it
- Early Thymectomy Is Associated With Long-Term Impairment of the Immune System: A Systematic Review.Frontiers in immunology · 2021Pooled it
- Reconstitution of thymopoiesis via implantation of cryopreserved cultured thymus tissue into athymic recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Current and Future Therapeutic Approaches for Thymic Stromal Cell Defects.Frontiers in immunology · 2021Review
- The immune system in infants: Relevance to xenotransplantation.Pediatric transplantation · 2020Review
- Histopathologic assessment of cultured human thymus.PloS one · 2020Article
- Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models.Frontiers in immunology · 2020Review
- T cell Tolerance in Early Life.Frontiers in immunology · 2020Review
- FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.The Journal of clinical investigation · 2019Article
- Review
- Treatment of Pediatric Acute Graft-versus-Host Disease-Lessons from Primary Immunodeficiency?Frontiers in immunology · 2017Review
- MicroRNA-205 Maintains T Cell Development following Stress by Regulating Forkhead Box N1 and Selected Chemokines.The Journal of biological chemistry · 2016Article
- Primary Immune Deficiency Treatment Consortium (PIDTC) update.The Journal of allergy and clinical immunology · 2016Review
- Three distinct subsets of thymic epithelial cells in rats and mice defined by novel antibodies.PloS one · 2014Article
- Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.European journal of immunology · 2013Article
- FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program.Frontiers in immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A functional thymus develops after cultured thymus tissue is transplanted into subjects with complete DiGeorge anomaly. To gain insight into how the process occurs, 7 post-transplantation thymus biopsy tissues were evaluated. In 5 of 7 biopsies, the thymus appeared to be predominantly cortex with thymocytes expressing cortical markers. Unexpectedly, the epithelium expressed both cortical [cortical dendritic reticulum antigen 2 (CDR2)] and medullary [cytokeratin (CK) 14] markers. Early medullary development was suggested by epithelial cell adhesion molecule (EpCAM) reactivity in small areas of biopsies. Two other biopsies had distinct mature cortex and medulla with normal restriction of CK14 to the medulla and subcapsular cortex, and of CDR2 to cortex. These data are consistent with a model in which thymic epithelium contains CK14+ "progenitor epithelial cells". After transplantation these cells proliferate as CK14+CDR2+ thymic epithelial cells that are associated with cortical thymocytes. Later these cells differentiate into distinct cortical and medullary epithelia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.