Evidence map›Paper›PMID 21565403›Full record

ReviewCell calcium2011

Biological functions and transcriptional targets of CaRF in neurons.

Anne E West

Abstract readReview
In one paragraph

Review in Cell calcium, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Anne E WestDepartment of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA. west@neuro.duke.edu
Duke Medical Center · US

Funding

Epigenetic Regulation of Transcriptional Repression by Drugs of AbuseR01DA022202 · NIDA · DUKE UNIVERSITY · PI WEST, ANNE ELIZABETH · 2006 to 2010
$1.7M
NIDA NIH HHS 1-R01-DA022202NIDA NIH HHS R01 DA022202
6 · The paper itself

Abstract

Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons. Here I review evidence for the biological functions and transcriptional targets of CaRF in the brain and discuss potential mechanisms by which calcium-activated signaling pathways may modulate CaRF-dependent transcription. These data paint an emerging picture of CaRF as a regulatory nexus for signaling pathways that control aspects of synaptic development and neuronal function.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCalcium SignalingMiceNeuronsTranscription FactorsTranscription, GeneticBrain-Derived Neurotrophic FactorCarf protein, mouseTranscription Factors

Identifiers

PMID21565403
PMCPMC3114298
OpenAlexW2161888326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.