Trial reportThe American journal of cardiology2011
Effect of peripheral arterial disease on functional and clinical outcomes in patients with heart failure (from HF-ACTION).
Trial report in The American journal of cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Heart failure, peripheral artery disease, and dapagliflozin: a patient-level meta-analysis of DAPA-HF and DELIVER.European heart journal · 2023Pooled it
- Clinical Outcomes Following Exercise Rehabilitation in People with Multimorbidity: A Systematic Review.Journal of rehabilitation medicine · 2023Pooled it
- Impact of Peripheral Artery Disease in Patients With Heart Failure Undergoing Transcatheter Mitral Valve Repair: The COAPT Trial.Journal of the American Heart Association · 2023Trial
- A cardiovascular-motor axis framework for perfusion-mediated motor impairment.International journal of cardiology. Heart & vasculature · 2026Review
- Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure.Heart failure reviews · 2026Article
- Article
- Association of polycythemia with outcomes of acute decompensated heart failure: A matched and weighted cohort analysis.PloS one · 2026Article
- Impact of immigration on outcomes following acute decompensated heart failure: A retrospective cohort study.ESC heart failure · 2025Article
- Temporal trends in acute decompensated heart failure outcomes: A single-center 11-year retrospective analysis.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Statin therapy impact on Long-Term outcomes in acute heart Failure: Retrospective analysis of hospitalized patients.International journal of cardiology. Heart & vasculature · 2024Article
- Development a nomogram prognostic model for survival in heart failure patients based on the HF-ACTION data.BMC medical informatics and decision making · 2024Article
- Marital status impact on the outcomes of patients admitted for acute decompensation of heart failure: A retrospective, single-center, analysis.Clinical cardiology · 2023Article
- Predictors of Changes in Peak Oxygen Uptake After Outpatient Cardiac Rehabilitation: Importance of Cardiac Rehabilitation Attendance.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- Initial diastolic dysfunction is a powerful predictor of 5-year mortality in peripheral arterial disease patients undergoing percutaneous transluminal angioplasty.Heart and vessels · 2021Article
- Prevalence of Chronic Heart Failure, Associated Factors, and Therapeutic Management in Primary Care Patients in Spain, IBERICAN Study.Journal of clinical medicine · 2021Article
- Association of Heart Failure With Outcomes Among Patients With Peripheral Artery Disease: Insights From EUCLID.Journal of the American Heart Association · 2021Article
- Recurrent Admissions for Acute Decompensated Heart Failure Among Patients With and Without Peripheral Artery Disease: The ARIC Study.Journal of the American Heart Association · 2020Article
- Prevalence of peripheral arterial disease in patients with heart failure with preserved ejection fraction.Clinics (Sao Paulo, Brazil) · 2019Observational
- Is Time of the Essence? The Impact of Time of Hospital Presentation in Acute Heart Failure: Insights From ASCEND-HF Trial.JACC. Heart failure · 2018Article
- Effect of peripheral vascular disease on mortality in cardiac transplant recipients (from the United Network of Organ Sharing Database).The American journal of cardiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Patients with peripheral arterial disease (PAD) have lower functional capacity and worse clinical outcomes than age- and gender-matched patients. Few data exist on the relation of PAD to functional and clinical outcomes in patients with heart failure (HF). We sought to compare patients with HF with and without PAD for baseline functional capacity, response to exercise training, and clinical outcomes. HF-ACTION was a randomized controlled trial comparing usual care to structured exercise training plus usual care in patients with HF and an ejection fraction ≤35% and New York Heart Association class II to IV HF symptoms. Cardiopulmonary exercise testing occurred at enrollment, 3 months, and 1 year. Clinical follow-up occurred up to 4 years. Of the 2,331 HF-ACTION patients, 157 (6.8%) had PAD. At baseline, patients with HF and PAD had a shorter exercise duration (8.0 vs 9.8 minutes, p <0.001), lower peak oxygen consumption (12.5 vs 14.6 ml/kg/min, p <0.001), and shorter 6-minute walking distance (306 vs 371 m, p <0.001) compared to patients with HF without PAD. At 3 months patients with HF and PAD had less improvement on cardiopulmonary exercise testing (exercise duration 0.5 vs 1.1 minutes, p = 0.002; mean change in peak oxygen consumption 0.1 vs 0.6 ml/kg/min, p = 0.04) compared to patients with HF without PAD. PAD was an independent predictor of all-cause death or hospitalization (hazard ratio 1.31, 95% confidence interval 1.06 to 1.62, p = 0.011). Patients with PAD and HF had deceased baseline exercise capacity and decreased response to exercise training. In conclusion, PAD is an independent predictor of all-cause death or hospitalization in patients with HF.
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