ArticleThe British journal of dermatology2011
TRAIL contributes to the apoptotic effect of 13-cis retinoic acid in human sebaceous gland cells.
Article in The British journal of dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I.Disease markers · 2016Trial
- The Evolution of Topical Retinoids in Dermatology: A Cornerstone of Acne Management (1971-2025).The Journal of clinical and aesthetic dermatology · 2026Review
- Highlighting Ophthalmic Adverse Effects Associated with Isotretinoin.Life (Basel, Switzerland) · 2026Review
- Isotretinoin-Associated Serum Creatinine Elevation During Acne Treatment: A Case Report.Clinical, cosmetic and investigational dermatology · 2026Article
- Combining 675 nm Laser with Isotretinoin for Enhanced Acne Vulgaris Treatment Outcomes.Healthcare (Basel, Switzerland) · 2025Article
- Effects of Oral Isotretinoin on Skin and Serum Levels of FoxO3, TRAIL and p53 and Metabolic Parameters.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Isotretinoin promotes elimination of translation-competent HIV latent reservoirs in CD4T cells.PLoS pathogens · 2024Article
- Review
- Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris.Archives of dermatological research · 2023Article
- Teratogenic effect of isotretinoin in both fertile females and males (Review).Experimental and therapeutic medicine · 2021Review
- Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses.BioMed research international · 2020Article
- The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome.BioMed research international · 2019Article
- Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.Cellular signalling · 2018Article
- p53: key conductor of all anti-acne therapies.Journal of translational medicine · 2017Review
- Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer.Nutrition & metabolism · 2017Article
- Transcriptional changes in organoculture of full-thickness human skin following topical application of all-trans retinoic acid.International journal of cosmetic science · 2014Article
- [Isotretinoin. How should it be used?].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2013Article
- Isotretinoin oil-based capsule formulation optimization.TheScientificWorldJournal · 2013Article
- Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology.Anais brasileiros de dermatologiaArticle
- Presumed isotretinoin-induced extraocular myopathy.Journal of pharmacology & pharmacotherapeuticsArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe full mechanism of action of isotretinoin [13-cis retinoic acid (13-cis RA)] in treating acne is unknown. 13-cis RA induces key genes in sebocytes that are involved in apoptosis, including Tumor necrosis factor Related Apoptosis Inducing Ligand (TRAIL).
objectivesIn this study, we investigated the role of 13-cis RA-induced TRAIL within SEB-1 sebocytes.
methodsUsing 13-cis RA and recombinant human TRAIL (rhTRAIL) protein, we assessed induction of TRAIL and apoptosis in SEB-1 sebocytes, normal keratinocytes and patient skin biopsies.
resultsTreatment with rhTRAIL protein increased TUNEL-positive staining in SEB-1 sebocytes. TRAIL siRNA significantly decreased the percentage of TUNEL-positive SEB-1 sebocytes in response to 13-cis RA treatment. Furthermore, TRAIL expression increased in the skin of patients with acne after 1 week of isotretinoin therapy compared with baseline. TRAIL expression localized within sebaceous glands. Unlike sebocytes, TRAIL protein expression was not increased in normal human epidermal keratinocytes in response to 13-cis RA, nor did rhTRAIL induce apoptosis in keratinocytes, suggesting that TRAIL is key in the sebocyte-specific apoptotic effects of 13-cis RA.
conclusionsTaken together, our data suggest that TRAIL, like the neutrophil gelatinase-associated lipocalin, is involved in mediating 13-cis RA apoptosis of sebocytes.
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