ArticleJournal of AOAC International
Determination of anthocyanins in cranberry fruit and cranberry fruit products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation.
Article in Journal of AOAC International. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 81 citations in OpenAlex.
- Trial
- Effect of daily consumption of cranberry beverage on insulin sensitivity and modification of cardiovascular risk factors in adults with obesity: a pilot, randomised, placebo-controlled study.The British journal of nutrition · 2020Trial
- How Can Plant-Derived Natural Products and Plant Biotechnology Help Against Emerging Viruses?International journal of molecular sciences · 2025Review
- Principal Component Analysis Followed by Mahalanobis Distance Classification for Authentication ofAnalytical chemistry · 2025Article
- Dynamic Microbiome Responses to Structurally Diverse Anthocyanin-Rich Foods in a Western Diet Context.Nutrients · 2025Article
- Cranberry constituents prevent SOS-mediated filamentation of uropathogenicInfection and immunity · 2025Article
- Characterization of Anthocyanins Including Acetylated Glycosides from Highbush Blueberry (Foods (Basel, Switzerland) · 2025Article
- Influence of the Growing Region on the Phytochemical Composition and Antioxidant Properties of North American Cranberry Fruit (Plants (Basel, Switzerland) · 2023Article
- Article
- Advances in the Chemistry, Analysis and Adulteration of Anthocyanin Rich-Berries and Fruits: 2000-2022.Molecules (Basel, Switzerland) · 2023Review
- Polyphenolic profiles of a variety of wild berries from the Pacific Northwest region of North America.Current research in food science · 2023Article
- Acidic and Alkaline Conditions Affect the Growth of Tree Peony Plants via Altering Photosynthetic Characteristics, Limiting Nutrient Assimilation, and Impairing ROS Balance.International journal of molecular sciences · 2022Article
- A promising blueberry from Colombia: antioxidant activity, nutritional and phytochemical composition ofHeliyon · 2022Article
- Article
- Red Fruits Composition and Their Health Benefits-A Review.Foods (Basel, Switzerland) · 2022Review
- Cranberry (Antioxidants (Basel, Switzerland) · 2021Article
- Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model.Microbial cell (Graz, Austria) · 2021Article
- Effect of Hydrolysable Tannins and Anthocyanins on Recurrent Urinary Tract Infections in Nephropathic Patients: Preliminary Data.Nutrients · 2021Article
- Polyphenol Stability and Physical Characteristics of Sweetened Dried Cranberries.Foods (Basel, Switzerland) · 2020Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A single-laboratory validation study was conducted on an HPLC method for the detection and quantification of cyanidin-3-O-galactoside (C3Ga), cyanidin-3-O-glucoside (C3GI), cyanidin-3-O-arabinoside (C3Ar), peonidin-3-O-galactoside (P3Ga), and peonidin-3-O-arabinoside (P3Ar) in cranberry fruit (Vaccinium macrocarpon Aiton) raw material and finished products. An extraction procedure using a combination of sonication and shaking with acidified methanol was optimized for all five anthocyanins in freeze-dried cranberry fruit and finished products (commercial extract powder, juice, and juice cocktail). Final extract solutions were analyzed by HPLC using a C18 RP column. Calibration curves for all anthocyanin concentrations had correlation coefficients (r2) of > or = 99.8%. The method detection limits for C3Ga, C3Gl, C3Ar, P3Ga, and P3Ar were estimated to be 0.018, 0.016, 0.006, 0.013, and 0.011 microg/mL, respectively. Separation was achieved with a chromatographic run time of 35 min using a binary mobile phase with gradient elution. Quantitative determination performed in triplicate on four test materials on each of 3 days (n = 12) resulted in RSD(r) from 1.77 to 3.31%. Analytical range, as defined by the calibration curves, was 0.57-36.53 microg/mL for C3Ga, 0.15-9.83 microg/mL for C3GI, 0.28-17.67 microg/mL for C3Ar, 1.01-64.71 microg/mL for P3Ga, and 0.42-27.14 microg/mL for P3Ar. For solid materials prepared by the described method, this translates to 0.06-3.65 mglg for C3Ga, 0.02-0.98 mg/g for C3Gl, 0.03-1.77 mg/g for C3Ar, 0.10-6.47 mg/g for P3Ga, and 0.04-2.71 mg/g for P3Ar.
Indexed as
Identifiers
21563679PMC3302353W26721930What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.