ArticleProtein science : a publication of the Protein Society2011
TMKink: a method to predict transmembrane helix kinks.
Article in Protein science : a publication of the Protein Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Conformational Flexibility of Transmembrane Helices: How it Works and Where it Matters.Chemical reviews · 2026Review
- Early adolescent brain markers of late adolescent academic functioning.Brain imaging and behavior · 2019Article
- Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy.Nature communications · 2019Article
- Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis.Chemical reviews · 2019Article
- Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices.Journal of the American Chemical Society · 2017Article
- Evolution of the α-Subunit of Na/K-ATPase from Paramecium to Homo sapiens: Invariance of Transmembrane Helix Topology.Journal of molecular evolution · 2016Article
- Molecular Properties of Globin Channels and Pores: Role of Cholesterol in Ligand Binding and Movement.Frontiers in physiology · 2016Article
- Examining the Conservation of Kinks in Alpha Helices.PloS one · 2016Article
- Topological analysis of the Escherichia coli WcaJ protein reveals a new conserved configuration for the polyisoprenyl-phosphate hexose-1-phosphate transferase family.Scientific reports · 2015Article
- Computational modeling of membrane proteins.Proteins · 2015Review
- Transmembrane helices in "classical" nuclear reproductive steroid receptors: a perspective.Nuclear receptor signaling · 2015Article
- Article
- High-resolution modeling of transmembrane helical protein structures from distant homologues.PLoS computational biology · 2014Article
- Computational prediction of kink properties of helices in membrane proteins.Journal of computer-aided molecular design · 2014Article
- The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation.Structure (London, England : 1993) · 2013Article
- Assembly of the transmembrane domain of E. coli PhoQ histidine kinase: implications for signal transduction from molecular simulations.PLoS computational biology · 2013Article
- A transmembrane domain and GxxxG motifs within L2 are essential for papillomavirus infection.Journal of virology · 2013Article
- Structural differences between thermophilic and mesophilic membrane proteins.Protein science : a publication of the Protein Society · 2012Article
- Statistical analyses and computational prediction of helical kinks in membrane proteins.Journal of computer-aided molecular design · 2012Article
- Molecular dissection of TatC defines critical regions essential for protein transport and a TatB-TatC contact site.Molecular microbiology · 2012Article
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Authors and funding
3 authors.
Funding
Abstract
A hallmark of membrane protein structure is the large number of distorted transmembrane helices. Because of the prevalence of bends, it is important to not only understand how they are generated but also to learn how to predict their occurrence. Here, we find that there are local sequence preferences in kinked helices, most notably a higher abundance of proline, which can be exploited to identify bends from local sequence information. A neural network predictor identifies over two-thirds of all bends (sensitivity 0.70) with high reliability (specificity 0.89). It is likely that more structural data will allow for better helix distortion predictors with increased coverage in the future. The kink predictor, TMKink, is available at http://tmkinkpredictor.mbi.ucla.edu/.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.