ArticleThe Prostate2012
EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer.
Article in The Prostate, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The role of CD147 expression in prostate cancer: a systematic review and meta-analysis.Drug design, development and therapy · 2016Pooled it
- Transcription factor p53-mediated activation of miR-519d-3p and downregulation of E2F1 attenuates prostate cancer growth and metastasis.Cancer gene therapy · 2022Article
- Article
- Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes.Journal of experimental & clinical cancer research : CR · 2019Article
- Review
- The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion.Molecular oncology · 2017Article
- EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Prostate cancer relevant antigens and enzymes for targeted drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Cofilin drives cell-invasive and metastatic responses to TGF-β in prostate cancer.Cancer research · 2014Article
- Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.Cancer research · 2013Article
- CCL2 disrupts the adherens junction: implications for neuroinflammation.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Role of emmprin in endometrial cancer.BMC cancer · 2012Article
- In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147.PloS one · 2012Article
- TGF-beta regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1.Anticancer research · 2011Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProteins on cell surface play important roles during cancer progression and metastasis via their ability to mediate cell-to-cell interactions and navigate the communication between cells and the microenvironment.
methodsIn this study a targeted proteomic analysis was conducted to identify the differential expression of cell surface proteins in human benign (BPH-1) versus malignant (LNCaP and PC-3) prostate epithelial cells. We identified EMMPRIN (extracellular matrix metalloproteinase inducer) as a key candidate and shRNA functional approaches were subsequently applied to determine the role of EMMPRIN in prostate cancer cell adhesion, migration, invasion as well as cytoskeleton organization.
resultsEMMPRIN was found to be highly expressed on the surface of prostate cancer cells compared to BPH-1 cells, consistent with a correlation between elevated EMMPRIN and metastasis found in other tumors. No significant changes in cell proliferation, cell cycle progression, or apoptosis were detected in EMMPRIN knockdown cells compared to the scramble controls. Furthermore, EMMPRIN silencing markedly decreased the ability of PC-3 cells to form filopodia, a critical feature of invasive behavior, while it increased expression of cell-cell adhesion and gap junction proteins.
conclusionsOur results suggest that EMMPRIN regulates cell adhesion, invasion, and cytoskeleton reorganization in prostate cancer cells. This study identifies a new function for EMMPRIN as a contributor to prostate cancer cell-cell communication and cytoskeleton changes towards metastatic spread, and suggests its potential value as a marker of prostate cancer progression to metastasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.