ArticleCerebellum (London, England)2011
Cerebellar nicotinic cholinergic receptors are intrinsic to the cerebellum: implications for diverse functional roles.
Article in Cerebellum (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Theobromine synergizes with nicotine to enhance animal motor abilities and cognitive function.Behavioural pharmacology · 2025Article
- Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour.The European journal of neuroscience · 2024Article
- New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment.Frontiers in cellular neuroscience · 2024Review
- Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.Scientific reports · 2017Article
- Imaging α4β2 Nicotinic Acetylcholine Receptors (nAChRs) in Baboons with [Molecular imaging and biology · 2017Article
- Analysis of gait in rats with olivocerebellar lesions and ability of the nicotinic acetylcholine receptor agonist varenicline to attenuate impairments.Behavioural brain research · 2015Article
- Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit.Frontiers in cellular neuroscience · 2015Review
- Chronic functional bowel syndrome enhances gut-brain axis dysfunction, neuroinflammation, cognitive impairment, and vulnerability to dementia.Neurochemical research · 2014Review
- Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia.Neuropharmacology · 2013Article
- Remote brain network changes after unilateral cortical impact injury and their modulation by acetylcholinesterase inhibition.Journal of neurotrauma · 2013Article
- Cerebellar theta burst stimulation modulates short latency afferent inhibition in Alzheimer's disease patients.Frontiers in aging neuroscience · 2013Article
- Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus.Psychopharmacology · 2013Article
- Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.Neurobiology of learning and memory · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Although recent studies have delineated the specific nicotinic subtypes present in the mammalian cerebellum, very little is known about their location or function within the cerebellum. This is of increased interest since nicotinic receptors (nAChRs) in the cerebellum have recently been implicated in the pathology of autism spectrum disorders. To begin to better understand the roles of these heteromeric nAChRs in the cerebellar circuitry and their therapeutic potential as targets for drug development, we used various chemical and stereotaxic lesion models in conjunction with slice electrophysiology to examine how specific heteromeric nAChR subtypes may influence the surrounding cerebellar circuitry. Using subunit-specific immunoprecipitation of radiolabeled nAChRs in the cerebella following N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, p-chloroamphetamine, and pendunculotomy lesions, we show that most, if not all, cerebellar nicotinic receptors are present in cells within the cerebellum itself and not in extracerebellar afferents. Furthermore, we demonstrate that the β4-containing, but not the β2-containing, nAChRs intrinsic to the cerebellum can regulate inhibitory synaptic efficacy at two major classes of cerebellar neurons. These tandem findings suggest that nAChRs may present a potential drug target for disorders involving the cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.