ArticleEuropean radiology2011
Molecular and functional ultrasound imaging in differently aggressive breast cancer xenografts using two novel ultrasound contrast agents (BR55 and BR38).
Article in European radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 107 citations in OpenAlex.
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- Improved Nondestructive Ultrasound Molecular Imaging With Lightweight Convolutional Neural Network.IEEE transactions on medical imaging · 2026Article
- Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
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- Molecular Ultrasound Imaging Depicts the Modulation of Tumor Angiogenesis by Acetylsalicylic Acid.International journal of molecular sciences · 2023Article
- Aptamer-Functionalized Microbubbles Targeted to P-selectin for Ultrasound Molecular Imaging of Murine Bowel Inflammation.Molecular imaging and biology · 2023Article
- Ultrasound-assisted brain delivery of nanomedicines for brain tumor therapy: advance and prospect.Journal of nanobiotechnology · 2022Review
- Dynamic Filtering of Adherent and Non-adherent Microbubble Signals Using Singular Value Thresholding and Normalized Singular Spectrum Area Techniques.Ultrasound in medicine & biology · 2021Article
- Emerging methods in radiology.Der Radiologe · 2020Review
- Nondestructive Detection of Targeted Microbubbles Using Dual-Mode Data and Deep Learning for Real-Time Ultrasound Molecular Imaging.IEEE transactions on medical imaging · 2020Article
- Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Efficacy of Affibody-Based Ultrasound Molecular Imaging of Vascular B7-H3 for Breast Cancer Detection.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Evaluation of ductal carcinoma in situ grade via triple-modal molecular imaging of B7-H3 expression.NPJ breast cancer · 2020Article
- Validation of Normalized Singular Spectrum Area as a Classifier for Molecularly Targeted Microbubble Adherence.Ultrasound in medicine & biology · 2019Article
- Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma.IEEE transactions on bio-medical engineering · 2019Article
- Endoglin-targeted contrast-enhanced ultrasound imaging in hepatoblastoma xenografts.Oncology letters · 2018Article
- A new preclinical ultrasound platform for widefield 3D imaging of rodents.The Review of scientific instruments · 2018Article
- Preparation and Imaging Investigation of Dual-targeted CScientific reports · 2018Article
- Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasisOncotarget · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo characterise clinically translatable long-circulating (BR38) and VEGFR2-targeted (BR55) microbubbles (MB) and to assess their ability to discriminate breast cancer models with different aggressiveness.
methodsThe circulation characteristics of BR38 and BR55 were investigated in healthy mice. The relative blood volume (rBV) of MDA-MB-231 (n = 5) or MCF-7 (n = 6) tumours was determined using BR38. In the same tumours in-vivo binding specificity of BR55 was tested and VEGFR2 expression assessed. Data validation included quantitative immunohistological analysis.
resultsBR38 had a longer blood half-life than BR55 (>600 s vs. 218 s). BR38-enhanced ultrasound showed greater vascularisation in MDA-MB-231 tumours (p = 0.022), which was in line with immunohistology (p = 0.033). In-vivo competitive binding experiments proved the specificity of BR55 to VEGFR2 (p = 0.027). Binding of BR55 was significantly higher in MDA-MB-231 than in MCF-7 tumours (p = 0.049), which corresponded with the VEGFR2 levels found histologically (p = 0.015). However, differences became smaller when normalising the levels of BR55 to the rBV.
conclusionsBR38 and BR55 are well suited to characterising and distinguishing breast cancers with different angiogenesis and aggressiveness. Long-circulating BR38 MB allow extensive 3-dimensional examinations of larger or several organs. BR55 accumulation faithfully reflects the VEGFR2 status in tumours and depicts even small differences in angiogenesis.
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