ArticleThe ISME journal2011
Population genomics of Sinorhizobium medicae based on low-coverage sequencing of sympatric isolates.
Article in The ISME journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Polyhydroxyalkanoate synthesis by Sinorhizobium meliloti drives a host-specific collapse in symbiosis with Medicago sativa.Research square · 2025Article
- Closed genomes of commercial inoculant rhizobia provide a blueprint for management of legume inoculation.Applied and environmental microbiology · 2025Article
- Impacts of Natural Selection on Evolution of Core and Symbiotically Specialized (International journal of molecular sciences · 2023Article
- Scent of a Symbiont: The Personalized Genetic Relationships of Rhizobium-Plant Interaction.International journal of molecular sciences · 2022Review
- Complete Genome of Sinorhizobium meliloti AK76, a Symbiont of Wild Diploid Medicago lupulina from the Mugodgary Mountain Region.Microbiology resource announcements · 2022Article
- Defining theGenes · 2021Article
- Symbiosis genes show a unique pattern of introgression and selection within aMicrobial genomics · 2020Article
- Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium.The ISME journal · 2019Article
- Genome-Wide Association Analyses in the Model RhizobiummSphere · 2018Article
- Rhizobia: from saprophytes to endosymbionts.Nature reviews. Microbiology · 2018Review
- Contribution of Mobile Group II Introns toFrontiers in microbiology · 2018Review
- Is there sufficientApplied soil ecology : a section of Agriculture, Ecosystems & Environment · 2017Article
- The underlying process of early ecological and genetic differentiation in a facultative mutualistic Sinorhizobium meliloti population.Scientific reports · 2017Article
- Association mapping reveals novel serpentine adaptation gene clusters in a population of symbiotic Mesorhizobium.The ISME journal · 2017Article
- The early events underlying genome evolution in a localized Sinorhizobium meliloti population.BMC genomics · 2016Article
- The repABC Plasmids with Quorum-Regulated Transfer Systems in Members of the Rhizobiales Divide into Two Structurally and Separately Evolving Groups.Genome biology and evolution · 2015Article
- Genomic characterization of Sinorhizobium meliloti AK21, a wild isolate from the Aral Sea Region.SpringerPlus · 2015Article
- Bacterial genospecies that are not ecologically coherent: population genomics of Rhizobium leguminosarum.Open biology · 2015Article
- Replicon-dependent differentiation of symbiosis-related genes in Sinorhizobium strains nodulating Glycine max.Applied and environmental microbiology · 2014Article
- Comparative genomics of the core and accessory genomes of 48 Sinorhizobium strains comprising five genospecies.Genome biology · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the genomic diversity of a local population of the symbiotic bacterium Sinorhizobium medicae, isolated from the roots of wild Medicago lupulina plants, in order to assess genomic diversity, to identify genomic regions influenced by duplication, deletion or strong selection, and to explore the composition of the pan-genome. Partial genome sequences of 12 isolates were obtained by Roche 454 shotgun sequencing (average 5.3 Mb per isolate) and compared with the published sequence of S. medicae WSM 419. Homologous recombination appears to have less impact on the polymorphism patterns of the chromosome than on the chromid pSMED01 and megaplasmid pSMED02. Moreover, pSMED02 is a hot spot of insertions and deletions. The whole chromosome is characterized by low sequence polymorphism, consistent with the high density of housekeeping genes. Similarly, the level of polymorphism of symbiosis genes (low) and of genes involved in polysaccharide synthesis (high) may reflect different selection. Finally, some isolates carry genes that may confer adaptations that S. medicae WSM 419 lacks, including homologues of genes encoding rhizobitoxine synthesis, iron uptake, response to autoinducer-2, and synthesis of distinct polysaccharides. The presence or absence of these genes was confirmed by PCR in each of these 12 isolates and a further 27 isolates from the same population. All isolates had rhizobitoxine genes, while the other genes were co-distributed, suggesting that they may be on the same mobile element. These results are discussed in relation to the ecology of Medicago symbionts and in the perspective of population genomics studies.
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