ArticleGenes and immunity2011
The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis.
Article in Genes and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- JMY polymorphism is related to severity of ankylosing spondylitis in Chinese Han patients.Genetic testing and molecular biomarkers · 2013Trial
- Context-Dependent Functions of KDM6 Lysine Demethylases in Physiology and Disease.Advances in experimental medicine and biology · 2023Article
- One genome, many cell states: epigenetic control of innate immunity.Current opinion in immunology · 2022Review
- Beyond receptors and signaling: epigenetic factors in the regulation of innate immunity.Immunology and cell biology · 2015Review
- Examining the impact of gene variants on histone lysine methylation.Biochimica et biophysica acta · 2014Review
- Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.British journal of pharmacology · 2014Review
- The roles of Jumonji-type oxygenases in human disease.Epigenomics · 2014Review
- Histone lysine demethylases as targets for anticancer therapy.Nature reviews. Drug discovery · 2013Review
- JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients: a case-control study.PloS one · 2013Article
- Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets.Pharmaceuticals (Basel, Switzerland) · 2012Article
- Molecular mechanisms and potential functions of histone demethylases.Nature reviews. Molecular cell biology · 2012Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Associations with disease identified by genome-wide association studies (GWAS) must be replicated and refined to validate causative variants. In the Wellcome Trust Case Control Consortium (WTCCC) GWAS using 14 500 non-synonymous single nucleotide polymorphisms (nsSNP), rs11062385 (a nsSNP in JARID1A) showed nominal association with ankylosing spondylitis (AS) (P=0.0006, odds ratio (OR)=1.26, 95% confidence interval (95% CI)=1.1-1.4). To replicate and refine the association of JARID1A, rs11062385 was genotyped in 730 further cases and compared with allele frequencies in non-AS disease cohorts typed by WTCCC. We replicated the initial association (P=0.04, OR=1.16, 95% CI=1.01-1.34) and identified a strengthened association with AS in a meta-analysis of this new study combined with the original WTCCC study (P=0.0001, OR=1.21, 95% CI=1.10-1.33). We also genotyped nine further intronic tagging SNPs in JARID1A in 1604 AS cases and 1020 new control samples, but none was associated with AS. JARID1A or a locus in strong linkage disequilibrium with it is a positional candidate for susceptibility to AS.
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Registered trials
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