Evidence map›Paper›PMID 21562484›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011

Blockade of 5-HT2 receptor selectively prevents MDMA-induced verbal memory impairment.

J H P van Wel, K P C Kuypers, E L Theunissen, W M Bosker, K Bakker, J G Ramaekers

Open access · bronzeAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Antihypertensive withdrawal for the prevention of cognitive decline.The Cochrane database of systematic reviews · 2016
    Pooled it
  4. Pooled it
  5. MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Trial
  6. Altered Insula Connectivity under MDMA.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Moving beyond 5-HTPsychopharmacology · 2026
    Article
  12. Review
  13. Observational
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. A single dose of cocaine enhances prospective memory performance.Journal of psychopharmacology (Oxford, England) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J H P van WelDepartment Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands. Janelle.vanWel@maastrichtuniversity.nl
K P C Kuypers
E L Theunissen
W M Bosker
K Bakker
J G Ramaekers
Maastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) or 'ecstasy' has been associated with memory deficits during abstinence and intoxication. The human neuropharmacology of MDMA-induced memory impairment is unknown. This study investigated the role of 5-HT(2A) and 5-HT(1A) receptors in MDMA-induced memory impairment. Ketanserin is a 5-HT(2A) receptor blocker and pindolol a 5-HT(1A) receptor blocker. It was hypothesized that pretreatment with ketanserin and pindolol would protect against MDMA-induced memory impairment. Subjects (N=17) participated in a double-blind, placebo-controlled, within-subject design involving six experimental conditions consisting of pretreatment (T1) and treatment (T2). T1 preceded T2 by 30 min. T1-T2 combinations were: placebo-placebo, pindolol 20 mg-placebo, ketanserin 50 mg-placebo, placebo-MDMA 75 mg, pindolol 20 mg-MDMA 75 mg, and ketanserin 50 mg-MDMA 75 mg. Memory function was assessed at Tmax of MDMA by means of a word-learning task (WLT), a spatial memory task and a prospective memory task. MDMA significantly impaired performance in all memory tasks. Pretreatment with a 5-HT(2A) receptor blocker selectively interacted with subsequent MDMA treatment and prevented MDMA-induced impairment in the WLT, but not in the spatial and prospective memory task. Pretreatment with a 5-HT(1A) blocker did not affect MDMA-induced memory impairment in any of the tasks. Together, the results demonstrate that MDMA-induced impairment of verbal memory as measured in the WLT is mediated by 5-HT(2A) receptor stimulation.

Indexed as

AdultDouble-Blind MethodFemaleHumansMaleMemory DisordersN-Methyl-3,4-methylenedioxyamphetaminePlacebosSerotonin 5-HT2 Receptor AntagonistsSerotonin AgentsYoung AdultN-Methyl-3,4-methylenedioxyamphetaminePlacebosSerotonin 5-HT2 Receptor AntagonistsSerotonin Agents

Identifiers

PMID21562484
PMCPMC3154112
OpenAlexW2114461993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.