Trial reportCirculation. Cardiovascular genetics2011
Common variants in epithelial sodium channel genes contribute to salt sensitivity of blood pressure: The GenSalt study.
Trial report in Circulation. Cardiovascular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00721721 (Genetic Epidemiology Network of Salt Sensitivity), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology Network of Salt Sensitivity
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples.The Journal of nutrition · 2020Pooled it
- The epithelial sodium channel γ-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses.Hypertension (Dallas, Tex. : 1979) · 2011Pooled it
- Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.American journal of hypertension · 2018Trial
- Common variants in the Na(+)-coupled bicarbonate transporter genes and salt sensitivity of blood pressure: the GenSalt study.Journal of human hypertension · 2016Trial
- Genome-wide linkage and regional association study of blood pressure response to the cold pressor test in Han Chinese: the genetic epidemiology network of salt sensitivity study.Circulation. Cardiovascular genetics · 2014Trial
- Blood pressure responses to dietary sodium and potassium interventions and the cold pressor test: the GenSalt replication study in rural North China.American journal of hypertension · 2014Trial
- Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension.Hypertension (Dallas, Tex. : 1979) · 2013Trial
- Genetic Risk for Hypertension Increases the Effect of Salt Intake on the Risk of Incident CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Multifaceted roles of Epac signaling in renal functions.The Biochemical journal · 2025Review
- Epithelial NaComprehensive Physiology · 2024Review
- Genetic variation in salt taste receptors impact salt intake and blood pressure.Scientific reports · 2023Article
- Upregulation of Mineralocorticoid Receptor Contributes to Development of Salt-Sensitive Hypertension after Ischemia-Reperfusion Injury in Rats.International journal of molecular sciences · 2022Article
- Sodium sensitivity of blood pressure in Chinese populations.Journal of human hypertension · 2020Review
- A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia.American journal of hypertension · 2019Article
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- Article
- Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives.American journal of hypertension · 2017Article
- Genetic susceptibility to salt-sensitive hypertension in a Han Chinese population: a validation study of candidate genes.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- micro-RNA screening and prediction model construction for diagnosis of salt-sensitive essential hypertension.Medicine · 2017Article
- Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity.American journal of physiology. Renal physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundRare mutations of the epithelial sodium channel (ENaC) lead to mendelian forms of salt-sensitive hypertension or salt-wasting hypotension. We aimed to examine the association between common variants in the ENaC genes and salt sensitivity of blood pressure (BP). METHODS AND
resultsA total of 1906 Han Chinese participated in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, which includes a 7-day low-sodium intake (51.3 mmol sodium/d) followed by a 7-day high-sodium intake (307.8 mmol sodium/d). Nine BP measurements were obtained at baseline and each intervention period using a random-zero sphygmomanometer. Single-nucleotide polymorphisms, both tagging and functional, from the 3 ENaC subunits, α, β, and γ (SCNN1A, SCNN1B, and SCNN1G), were genotyped. Multiple common single-nucleotide polymorphisms in SCNN1G were significantly associated with BP response to low-sodium intervention (rs4073930, P=1.7×10(-5); rs4073291, P=1.1×10(-5); rs7404408, P=1.9×10(-5); rs5735, P=3.0×10(-4); rs4299163, P=0.004; and rs4499238, P=0.002) even after correcting for multiple testing. For example, under an additive model, the minor allele G of SNP rs4073291 was associated with 1.33 mm Hg lower systolic BP reduction during low-sodium intervention.
conclusionsThis large dietary sodium intervention study indicates that common variants of ENaC subunits may contribute to the variation of BP response to dietary sodium intake. Future studies are warranted to confirm these findings in an independent population and to identify functional variants for salt sensitivity. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00721721.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.