ArticleMolecular biology of the cell2011
The two domains of centrin have distinct basal body functions in Tetrahymena.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Trypanosoma brucei centrin5 is enriched in the flagellum and interacts with other centrins in a calcium-dependent manner.FEBS open bio · 2019Article
- Motile Cilia: Innovation and Insight From Ciliate Model Organisms.Frontiers in cell and developmental biology · 2019Review
- Differential localization and functional specialization of centrin analogs in the parasitic ciliate Trichodina pediculus.Protoplasma · 2016Article
- Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus.Scientific reports · 2015Article
- ε-tubulin is essential in Tetrahymena thermophila for the assembly and stability of basal bodies.Journal of cell science · 2013Article
- Sfr13, a member of a large family of asymmetrically localized Sfi1-repeat proteins, is important for basal body separation and stability in Tetrahymena thermophila.Journal of cell science · 2013Article
- Article
- Discovery and functional evaluation of ciliary proteins in Tetrahymena thermophila.Methods in enzymology · 2013Article
- Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair.PloS one · 2013Article
- The two human centrin homologues have similar but distinct functions at Tetrahymena basal bodies.Molecular biology of the cell · 2012Article
- Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces.Molecular biology of the cell · 2012Article
- Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance.Cellular and molecular life sciences : CMLS · 2012Review
- Review
- Role of centrins 2 and 3 in organelle segregation and cytokinesis in Trypanosoma brucei.PloS one · 2012Article
- Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish.Cell cycle (Georgetown, Tex.) · 2011Article
- Sfr1, amSphereArticle
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6 authors at 1 institution in 1 country.
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Abstract
The basal body is a microtubule-organizing center responsible for organizing the cilium, a structure important for cell locomotion and sensing of the surrounding environment. A widely conserved basal body component is the Ca(2+)-binding protein centrin. Analyses of centrin function suggest a role in basal body assembly and stability; however, its molecular mechanisms remain unclear. Here we describe a mutagenic strategy to study the function and essential nature of the various structural features of Cen1 in the ciliate Tetrahymena. We find that the two domains of Cen1 are both essential, and examination of strains containing mutant CEN1 alleles indicates that there are two predominant basal body phenotypes: misorientation of newly assembled basal bodies and stability defects. The results also show that the two domains of Cen1 are able to bind Ca(2+) and that perturbation of Ca(2+) binding affects Cen1 function. In all, the data suggest that the two domains of Cen1 have distinct functions.
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