ArticleThe Journal of experimental biology2011
Fibroblasts from long-lived bird species are resistant to multiple forms of stress.
Article in The Journal of experimental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 87 citations in OpenAlex.
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- Chronic sublethal exposure to methylmercury lengthens telomeres in developing zebra finches.Environmental pollution (Barking, Essex : 1987) · 2025Article
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- Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity.Aging cell · 2025Article
- The resistance of domestic canine skin-derived fibroblasts to oxidative and non-oxidative chemical injury: implications of breed and body size.GeroScience · 2025Article
- Fmo induction as a tool to screen for pro-longevity drugs.GeroScience · 2024Article
- Primary Cell Culture as a Model System for Evolutionary Molecular Physiology.International journal of molecular sciences · 2024Review
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- Tendon-Derived Mesenchymal Stem Cells (TDSCs) as an In Vitro Model for Virological Studies in Wild Birds.Viruses · 2023Article
- Methionine Sources Differently Affect Production of Reactive Oxygen Species, Mitochondrial Bioenergetics, and Growth of Murine and Quail Myoblasts In Vitro.Current issues in molecular biology · 2023Article
- Establishment of the Primary Avian Gonadal Somatic Cell Lines for Cytogenetic Studies.Animals : an open access journal from MDPI · 2022Article
- Model systems and organisms for addressing inter- and intra-species variability in risk assessment.Regulatory toxicology and pharmacology : RTP · 2022Review
- Transient early life growth hormone exposure permanently alters brain, muscle, liver, macrophage, and adipocyte status in long-lived Ames dwarf mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- A new approach method for characterizing inter-species toxicodynamic variability.Journal of toxicology and environmental health. Part A · 2021Article
- Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging.GeroScience · 2021Article
- New Perspectives on Avian Models for Studies of Basic Aging Processes.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Evolutionary senescence theory postulates that aging results from the declining force of natural selection with increasing chronological age. A goal of comparative studies in the biology of aging is to identify genetic and biochemical mechanism(s) driving species-specific differences in the aging process that are the end product of life history trade-offs. We hypothesized that cells from long-lived bird species are more resistant to stress agents than are cells from short-lived species, and that cells from birds are more resistant to stress than are cells from relatively short-lived mammals of similar size. We tested primary fibroblast cultures from 35 species of free-living birds for their resistance to multiple forms of cellular stress and found that cell lines from longer-lived species were resistant to death caused by cadmium (R(2)=0.27, P=0.002), paraquat (R(2)=0.13, P=0.03), hydrogen peroxide (R(2)=0.09, P=0.07) and methyl methanesulfonate (R(2)=0.13, P=0.03), as well as to the metabolic inhibition seen in low-glucose medium (R(2)=0.37, P<0.01). They did not differ in their resistance to UV radiation, or to thapsigargin or tunicamycin, inducers of the unfolded protein response. These results were largely consistent even after accounting for the influence of body mass and phylogeny. Cell lines from longer-lived bird species also proliferate more rapidly than cells from short-lived birds, although there was no relationship between proliferation and stress resistance. Finally, avian fibroblasts were significantly more resistant than rodent fibroblasts to each of the tested stressors. These results support the idea that cellular resistance to injury may be an important contributor to the evolution of slow aging and long lifespan among bird species, and may contribute to the relatively long lifespan of birds compared with rodents of the same body size.
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