ReviewSchizophrenia bulletin2012
Impairment in functional capacity as an endophenotype candidate in severe mental illness.
Review in Schizophrenia bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Mapping the Interplay Between Childhood Trauma, Substance Use, and Psychopathology in Early Psychosis: A Network Analysis Approach.Schizophrenia bulletin · 2026Article
- Neurophysiological indices of face processing in people with psychosis and their siblings: An event-related potential study.The European journal of neuroscience · 2024Article
- Evaluation of a flexible assertive community treatment (FACT) program for patients with severe mental illness: an observational study in Salzburg, Austria.International journal of mental health systems · 2024Article
- Qualitative Analysis of the Content Validity of the Virtual Reality Functional Capacity Assessment Tool (VRFCAT) in Schizophrenia: A Multi-Stakeholder Perspective.Schizophrenia bulletin open · 2023Article
- Neurocognition and its association with adverse childhood experiences and familial risk of mental illness.Progress in neuro-psychopharmacology & biological psychiatry · 2022Article
- Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study.BJPsych open · 2022Article
- Article
- Functional deficits in attenuated psychosis syndrome and related conditions: Current and future treatment options.Schizophrenia research. Cognition · 2019Review
- Temporal Stability of Cognitive Functioning and Functional Capacity in Women with Posttraumatic Stress Disorder.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2019Article
- Factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder: Implications for genomic studies.Neuropsychology · 2016Article
- UCSD Performance-Based Skills Assessment (UPSA): validation of a Brazilian version in patients with schizophrenia.Schizophrenia research. Cognition · 2015Article
- Testing trait depression as a potential clinical domain in schizophrenia.Schizophrenia research · 2014Article
- Everyday functional ability across different phases of bipolar disorder.Psychiatry research · 2013Article
- Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Factor structure of neurocognition and functional capacity in schizophrenia: a multidimensional examination of temporal stability.Journal of the International Neuropsychological Society : JINS · 2013Article
- Neurocognitive function in bipolar disorder: a comparison between bipolar I and II disorder and matched controls.BMC psychiatry · 2013Article
- Functional outcomes, functional capacity, and cognitive impairment in schizotypal personality disorder.Schizophrenia research · 2013Article
- Profile difference between male and female psychiatric patients seeking certificate of disability.Oman medical journal · 2011Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Impairment in everyday functioning (also referred to as "disability") is a central feature of schizophrenia (SZ) and bipolar disorder, as well as other neuropsychiatric conditions. There is a genetic contribution to both SZ and bipolar illness (BPI), and the primary putative determinant of impairments in everyday functioning across these 2 conditions, cognitive impairments, also show substantial heritability and in fact have been proposed to be endophenotypes for these disorders. In this article, we review data and make our case that impairments in functional capacity, the functional abilities that result in functional disability, may also be a heritable trait that is common across neuropsychiatric illnesses such BPI and SZ. While there has been little previous research on the heritability of these abilities, it is an area receiving substantial research attention. We consider advances in the measurement of cognitive functioning in SZ that may facilitate the discovery of genetic influences on functional capacity. Functional capacity measures are proximal to real-world impairments, measured with suitable psychometric precision to be used in heritability analyses, and appear to be minimally influenced by environmental factors that may cause disability such as environmental factors, symptoms, and disability compensation. Our conclusion is that these functional capacity measures have potential to be the target of genetic analyses and that these measures should be considered across neuropsychiatric conditions where impairments in everyday functioning are present.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.