Evidence map›Paper›PMID 21562099›Full record

ArticleJournal of clinical microbiology2011

Comparison of in vitro susceptibility characteristics of Candida species from cases of invasive candidiasis in solid organ and stem cell transplant recipients: Transplant-Associated Infections Surveillance Network (TRANSNET), 2001 to 2006.

Shawn R Lockhart, Debra Wagner, Naureen Iqbal, Peter G Pappas, David R Andes, Carol A Kauffman, Lisa M Brumble, Susan Hadley, Randall Walker, James I Ito and 3 more

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 60 citations in OpenAlex.

  1. Trial
  2. Article
  3. Role of liposomal amphotericin B in intensive care unit: an expert opinion paper.Journal of anesthesia, analgesia and critical care · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Antimicrobial agents and chemotherapy · 2019
    Article
  9. Changes in the epidemiological landscape of invasive candidiasis.The Journal of antimicrobial chemotherapy · 2018
    Review
  10. Article
  11. Review
  12. Article
  13. Current Epidemiology ofClinical microbiology newsletter · 2014
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Shawn R LockhartMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Debra Wagner
Naureen Iqbal
Peter G Pappas
David R Andes
Carol A Kauffman
Lisa M Brumble
Susan Hadley
Randall Walker
James I Ito
John W Baddley
Tom Chiller
Benjamin J Park
Centers for Disease Control and Prevention · USBirmingham VA Medical Center · USCity Of Hope National Medical Center · USMayo Clinic · USNemours Children's Clinic · USTufts Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Wisconsin–Madison · USVA Ann Arbor Healthcare System · US

Funding

Vesicle-mediated drug resistance of Candida albicans biofilmR01AI073289 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, MITCHELL, AARON P · 2008 to 2025
$7.9M
NIAID NIH HHS R01 AI073289
6 · The paper itself

Abstract

Invasive fungal infections (IFI) are a major cause of morbidity and mortality among both solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients. Candida is the most common cause of IFI in SOT recipients and the second most common cause of IFI in HSCT recipients. We determined susceptibilities to fluconazole, voriconazole, itraconazole, posaconazole, amphotericin B, and caspofungin for 383 invasive Candida sp. isolates from SOT and HSCT recipients enrolled in the Transplant-Associated Infection Surveillance Network and correlated these results to clinical data. Fluconazole resistance in C. albicans, C. tropicalis, and C. parapsilosis isolates was low (1%), but the high percentage of C. glabrata and C. krusei isolates within this group of patients increased the overall percentage of fluconazole resistance to 16%. Voriconazole resistance was 3% overall but was 8% among C. glabrata isolates. On multivariable analysis, among HSCT recipients fluconazole nonsusceptibility was independently associated with C. glabrata, non-Hodgkin's lymphoma, cytomegalovirus (CMV) antigenemia, diabetes active at the time of the IFI, and any prior amphotericin B use; among SOT recipients, fluconazole nonsusceptibility was independently associated with any fluconazole use in the 3 months prior to the IFI, C. glabrata, ganciclovir use in the 3 months prior to the IFI, diabetes acquired since the transplant, and gender.

Indexed as

TransplantationAntifungal AgentsCandidaCandidiasis, InvasiveDrug Resistance, FungalHumansMicrobial Sensitivity TestsOrgan TransplantationStem Cell TransplantationAntifungal Agents

Identifiers

PMID21562099
PMCPMC3147873
OpenAlexW2096879424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.