ArticleThe American journal of clinical nutrition2011
Does maternal weight gain in pregnancy have long-term effects on offspring adiposity? A sibling study in a prospective cohort of 146,894 men from 136,050 families.
Article in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Maternal Overnutrition in Pregnancy Predicts Greater Body Mass Index Gains in Offspring by Early Midlife: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- Maternal weight gain in pregnancy and risk of obesity among offspring: a systematic review.Journal of obesity · 2014Pooled it
- Trial
- Greater Neonatal Fat-Free Mass and Similar Fat Mass Following a Randomized Trial to Control Excess Gestational Weight Gain.Obesity (Silver Spring, Md.) · 2018Trial
- Preventing excessive gestational weight gain--a secondary analysis of a cluster-randomised controlled trial.European journal of clinical nutrition · 2012Trial
- Lifestyle counseling during pregnancy and offspring weight development until four years of age: follow-up study of a controlled trial.Journal of negative results in biomedicine · 2012Trial
- Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course.Nature reviews. Cardiology · 2023Review
- Gestational weight gain in women with pre-pregnancy overweight or obesity and anthropometry of infants at birth.Frontiers in pediatrics · 2023Article
- Association of maternal obesity and gestational diabetes mellitus with overweight/obesity and fatty liver risk in offspring.World journal of gastroenterology · 2022Article
- Increased Gestational Weight Gain is Associated with a Higher Risk of Offspring Adiposity Before Five Years of Age: A Population-Based Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association Between Maternal Weight Gain in Different Periods of Pregnancy and the Risk of Venous Thromboembolism: A Retrospective Case-Control Study.Frontiers in endocrinology · 2022Article
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Frontiers in cellular and infection microbiology · 2022Review
- Maternal Diet During Pregnancy and Lactation and Child Food Preferences, Dietary Patterns, and Weight Outcomes: a Review of Recent Research.Current nutrition reports · 2021Review
- Optimal gestational weight gain for Chinese women - analysis from a longitudinal cohort with childhood follow-up.The Lancet regional health. Western Pacific · 2021Article
- The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose-tolerant mothers.Obesity science & practice · 2021Article
- Mid-pregnancy weight gain is associated with offspring adiposity outcomes in early childhood.Pediatric research · 2021Article
- Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand.BMC public health · 2021Article
- Article
- Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring.Prenatal diagnosis · 2020Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA small number of relatively small studies have found greater gestational weight gain to be associated with greater offspring body mass index (BMI; in kg/m(2)), but whether this association is caused by intrauterine mechanisms or by shared genetic and environmental risk factors for adiposity is unclear.
objectiveThe objective was to examine the association of greater maternal weight gain (MWG; postnatal weight minus weight at the first antenatal clinic assessment) with greater offspring BMI and to explore whether any observed association is explained by intrauterine mechanisms.
designThis was a prospective cohort study that used record linkage data (n = 146,894 individuals from 136,050 families). To compare the within-sibling and between-nonsibling associations, we used fixed- and between-cluster linear regression models.
resultsAssociations of MWG with later offspring BMI differed by the mother's early-pregnancy overweight or obesity status (P for interaction <0.0001). MWG was positively associated with BMI at a mean age of 18 y in the offspring of normal-weight women but only between unrelated men (0.07; 95% CI: 0.06, 0.07) per 1-kg greater MWG; no within-sibling association (0.00; 95% CI: -0.02, 0.02) per 1-kg greater MWG was found. In contrast, in overweight and obese women we found a within-sibling association (0.06; 95% CI: 0.01, 0.12) and an association between unrelated men (0.02; 95% CI: 0.01, 0.03) per 1-kg greater MWG.
conclusionIn normal-weight mothers, most of the association between MWG and later offspring BMI is explained by shared familial (genetic and early environmental) characteristics, whereas evidence indicates a contribution of intrauterine mechanisms in overweight and obese women.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.