ArticleThe Journal of biological chemistry2011
Disulfide-stabilized helical hairpin structure and activity of a novel antifungal peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli).
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 103 citations in OpenAlex.
- Production, Delivery, and Regulatory Aspects for Application of Plant-Based Anti-microbial Peptides: a Comprehensive Review.Probiotics and antimicrobial proteins · 2025Review
- Plant Defense Peptides: Exploring the Structure-Function Correlation for Potential Applications in Drug Design and Therapeutics.ACS omega · 2025Review
- Antimicrobial Plant Peptides: Structure, Classification, Mechanism and Therapeutic Potential.Current topics in medicinal chemistry · 2025Review
- Discovery of a Novel Insecticidal Peptide with a Cystine-Stabilized α-Helix/α-Helix Motif from the Venom of ScorpionMolecules (Basel, Switzerland) · 2024Article
- Identification and Characterization of CC-AMP1-like and CC-AMP2-like Peptides inJournal of proteome research · 2024Article
- Plant peptides - redefining an area of ribosomally synthesized and post-translationally modified peptides.Natural product reports · 2024Review
- Review
- Antifungal peptides from living organisms.Frontiers in microbiology · 2024Review
- Snakins: antimicrobial potential and prospects of genetic engineering for enhanced disease resistance in plants.Molecular biology reports · 2023Review
- Food Allergens of Plant Origin.Foods (Basel, Switzerland) · 2023Review
- Plant Antimicrobial Peptides: Insights into Structure-Function Relationships for Practical Applications.Current issues in molecular biology · 2023Review
- Epiphytic and Endophytic Fungi Colonizing Seeds of TwoMicroorganisms · 2023Article
- Rational Design of Plant Hairpin-like Peptide EcAMP1: Structural-Functional Correlations to Reveal Antibacterial and Antifungal Activity.Molecules (Basel, Switzerland) · 2022Article
- Development of a Therapeutic Peptide for Cachexia Suggests a Platform Approach for Drug-like Peptides.ACS pharmacology & translational science · 2022Article
- Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides.Journal of agricultural and food chemistry · 2022Article
- The evolution of the antimicrobial peptide database over 18 years: Milestones and new features.Protein science : a publication of the Protein Society · 2022Review
- Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds.Molecules (Basel, Switzerland) · 2021Article
- Identification of the amino-terminal fragment of Ara h 1 as a major target of the IgE-binding activity in the basic peanut protein fraction.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Article
- Defense Peptides From the α-Hairpinin Family Are Components of Plant Innate Immunity.Frontiers in plant science · 2020Review
- Barnyard Millet for Food and Nutritional Security: Current Status and Future Research Direction.Frontiers in genetics · 2020Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study presents purification, activity characterization, and (1)H NMR study of the novel antifungal peptide EcAMP1 from kernels of barnyard grass Echinochloa crus-galli. The peptide adopts a disulfide-stabilized α-helical hairpin structure in aqueous solution and thus represents a novel fold among naturally occurring antimicrobial peptides. Micromolar concentrations of EcAMP1 were shown to inhibit growth of several fungal phytopathogens. Confocal microscopy revealed intensive EcAMP1 binding to the surface of fungal conidia followed by internalization and accumulation in the cytoplasm without disturbance of membrane integrity. Close spatial structure similarity between EcAMP1, the trypsin inhibitor VhTI from seeds of Veronica hederifolia, and some scorpion and cone snail toxins suggests natural elaboration of different functions on a common fold.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.