ArticleThe New England journal of medicine2011
Evidence for human lung stem cells.
Article in The New England journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 163 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
163 citing papers in PubMed, 375 citations in OpenAlex.
- CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.Journal of tissue engineering and regenerative medicine · 2013Trial
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- Strategies for understanding the role of cellular heterogeneity in the pathogenesis of lung cancer: a cell model for chronic exposure to cigarette smoke extract.BMC pulmonary medicine · 2022Article
- Pathological observation of the effects of exposure to radioactive microparticles on experimental animals.Journal of radiation research · 2022Review
- C-KitIranian journal of basic medical sciences · 2022Article
- DNA Methylation Profiling in a Cigarette Smoke-Exposed Mouse Model of Airway Inflammation.International journal of chronic obstructive pulmonary disease · 2022Article
- Review
- Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.Nature communications · 2021Article
- Modulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair.Pharmacology & therapeutics · 2020Review
- PPA1 promotes NSCLC progression via a JNK- and TP53-dependent manner.Oncogenesis · 2019Article
- Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia.Respiratory research · 2019Article
- Differentiation of CD45‑/CD31+ lung side population cells into endothelial and smooth muscle cells in vitro.International journal of molecular medicine · 2019Article
- Molecular heterogeneity in lung cancer: from mechanisms of origin to clinical implications.International journal of medical sciences · 2019Review
- Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung.Stem cells international · 2019Article
- Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Retraction: Kajstura J et al. Evidence for Human Lung Stem Cells. N Engl J Med 2011;364:1795-806.The New England journal of medicine · 2018Article
- A basic study on self-reconstitution of alveolar epithelium-like cells by tissue stem cells in mouse lung.In vitro cellular & developmental biology. Animal · 2018Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2018-10-17Investigation by Company/Institution · Manipulation of Images · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author ·
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Authors and funding
24 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough progenitor cells have been described in distinct anatomical regions of the lung, description of resident stem cells has remained elusive.
methodsSurgical lung-tissue specimens were studied in situ to identify and characterize human lung stem cells. We defined their phenotype and functional properties in vitro and in vivo.
resultsHuman lungs contain undifferentiated human lung stem cells nested in niches in the distal airways. These cells are self-renewing, clonogenic, and multipotent in vitro. After injection into damaged mouse lung in vivo, human lung stem cells form human bronchioles, alveoli, and pulmonary vessels integrated structurally and functionally with the damaged organ. The formation of a chimeric lung was confirmed by detection of human transcripts for epithelial and vascular genes. In addition, the self-renewal and long-term proliferation of human lung stem cells was shown in serial-transplantation assays.
conclusionsHuman lungs contain identifiable stem cells. In animal models, these cells participate in tissue homeostasis and regeneration. They have the undemonstrated potential to promote tissue restoration in patients with lung disease. (Funded by the National Institutes of Health.).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.